Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells

被引：8

作者：

Fadaeinasab, Mehran ^{[1
]}

Karimian, Hamed ^{[2
]}

Omar, Hanita ^{[3
]}

Taha, Hairin ^{[4
]}

Khorasani, Arash ^{[5
]}

Banisalam, Behrooz ^{[5
]}

Ketuly, Kamal Aziz ^{[6
]}

Abdullah, Zanariah ^{[1
]}

机构：

[1] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

[2] Taylors Univ, Sch Med, Subang Jaya Selangor 47500, Malaysia

[3] Univ Malaya, Div Chem, Ctr Fdn Studies Sci, Kuala Lumpur 50603, Malaysia

[4] Univ Tenaga Nas, Inst Energy Infrastruct, Kajang 43000, Malaysia

[5] Univ Malaya, Inst Biol Sci, Fac Sci, Kuala Lumpur 50603, Malaysia

[6] Univ Duhok, Coll Med, Dept Med Chem, Duhok 78, Kurdistan Regio, Iraq

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 05期

关键词：

Rauvolfia reflexa; indole alkaloids; reflexin A; apoptosis; HCT-116; cells; acute toxicity; DRUGS;

D O I：

10.1080/10286020.2019.1588888

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC50 value of 30.24 +/- 0.75 mu M. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile. [GRAPHICS] .

引用

页码：474 / 488

页数：15

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