Use of apigenin from Cordia dichotoma in the treatment of colitis

被引：46
作者：
Ganjare, Anjali B. [1 ]
Nirmal, Sunil A. [1 ]
Patil, Anuja N. [1 ]
机构：
[1] Pravara Rural Coll Pharm, Dept Pharmacognosy, Loni, Maharashtra, India
来源：
FITOTERAPIA | 2011年 / 82卷 / 07期
关键词：
Cordia dichotoma; Apigenin; Ulcerative colitis; Myeloperoxidase; Malondialdehyde; Histopathology; INFLAMMATORY-BOWEL-DISEASE; ACETIC-ACID; OXIDATIVE STRESS; N-ACETYLCYSTEINE; TNF-ALPHA; FLAVONOIDS; EXPRESSION; ASSAY; RAT;
D O I：
10.1016/j.fitote.2011.06.008
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cordia dichotoma f. (Boraginaceae) is a small deciduous tree from India. The bark of was used in the treatment of ulcerative colitis (UC) and colic pain traditionally hence present work was undertaken to identify the phytoconstituent responsible for this activity. Apigenin is isolated by column chromatography from methanol fraction of crude methanol extract of C. dichotoma bark. Structure of apigenin is established by various spectroscopic studies. Apigenin (5 mg/kg, p.o.) showed significant healing and reduction in inflammatory enzymes when screened for UC. It can be concluded that apigenin from C. dichotoma bark may be responsible for the treatment of UC. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：1052 / 1056
页数：5
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