Chronic morphine-induced neuronal morphological changes in the ventral tegmental area in rats are reversed by electroacupuncture treatment

被引：29
作者：
Chu, Ning-ning
Xia, Wei
Yu, Peng
Hu, Ling
Zhang, Rong
Cui, Cai-Lian
机构：
[1] Peking Univ, Neurosci Res Inst, Beijing, Peoples R China
[2] Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing, Peoples R China
来源：
ADDICTION BIOLOGY | 2008年 / 13卷 / 01期
关键词：
electroacupuncture (EA); morphine dependence; morphine withdrawal; neuronal morphological changes; ventral tegmental area (VTA); rat;
D O I：
10.1111/j.1369-1600.2007.00092.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of this study was to observe the effect of electroacupuncture (EA) on chronic morphine-induced neuronal morphological changes in the ventral tegmental area (VTA) in rats at electron-microscopic level. Fourteen days of administering escalating doses of morphine induced pathological morphological changes of neurons in the VTA: the rough endoplasmic reticulum swelled, membrane configuration of the nucleus and mitochondria blurred, and structure of myelin sheath changed. Both 2 and 100 Hz EA treatment reversed the morphological alterations induced by chronic morphine administration. The findings provide new evidence that EA may serve as a potential therapy in treating opiate addiction.
引用
收藏
页码：47 / 51
页数：5
相关论文
共 26 条
[1]   Bioenergetics and the formation of mitochondrial reactive oxygen species [J].
Adam-Vizi, Vera ;
Chinopoulos, Christos .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2006, 27 (12) :639-645
[2]   Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats [J].
Chen, JH ;
Liang, J ;
Wang, GB ;
Han, JS ;
Cui, CL .
EXPERIMENTAL NEUROLOGY, 2005, 194 (02) :550-556
[3]   Peripheral electrical stimulation reversed the cell size reduction and increased BDNF level in the ventral tegmental area in chronic morphine-treated rats [J].
Chu, Ning-ning ;
Zuo, Yan-fang ;
Meng, Li ;
Lee, Dauid Yue-Wei ;
Han, Ji-sheng ;
Cui, Cai-lian .
BRAIN RESEARCH, 2007, 1182 :90-98
[4]   Endoplasmic reticulum:: A metabolic compartment [J].
Csala, M ;
Bánhegyi, G ;
Benedetti, A .
FEBS LETTERS, 2006, 580 (09) :2160-2165
[5]   Electroacupuncture facilitates recovery of male sexual behavior in morphine withdrawal rats [J].
Cui, GH ;
Ren, XW ;
Wu, LZ ;
Han, JS ;
Cui, CL .
NEUROCHEMICAL RESEARCH, 2004, 29 (02) :397-401
[6]  
D'Alberto A, 2004, J ALTERN COMPLEM MED, V10, P985
[7]   Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal [J].
Diana, M ;
Muntoni, AL ;
Pistis, M ;
Melis, M ;
Gessa, GL .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (03) :1037-1041
[8]  
GARCIAESTRADA J, 1988, GEN PHARMACOL-VASC S, V19, P841, DOI 10.1016/0306-3623(88)90220-0
[9]  
KOLUSHEVA GV, 1988, ZH NEVROPATOL PSIKH, V88, P67
[10]   Managing acute withdrawal syndrome on patients with heroin and morphine addiction by acupuncture therary [J].
Lu, PK ;
Lu, GP ;
Lu, DP ;
Lu, WI .
ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH, 2004, 29 (3-4) :187-195
123