Palladium-catalyzed conjugate addition of arylboronic acids to 2-substituted chromones in aqueous media

被引：12
|
作者：
Gerten, Anthony L. [1 ]
Stanley, Levi M. [1 ]
机构：
[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 49期
关键词：
Conjugate addition; Palladium; Flavanones; Protodeboronation; Catalysis; ASYMMETRIC 1,4-ADDITION; ENONES; FLAVANONES; MECHANISM;
D O I：
10.1016/j.tetlet.2016.10.084
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed conjugate additions of arylboronic acids to 2-alkylchromones are reported. The conjugate additions occur in aqueous media in the presence of a catalyst generated from palladium trifluoroacetate and 1,10-phenanthroline, and the flavanone derivatives containing a fully-substituted carbon center are formed in up to 90% yield. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5460 / 5463
页数：4
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