Transduction peptides: from technology to physiology

被引:430
作者
Joliot, A
Prochiantz, A
机构
[1] Ecole Normale Super, CNRS, UMR 5242, Homeoprot Cell Biol Grp, F-75230 Paris 05, France
[2] Ecole Normale Super, CNRS, UMR 8542, Dev & Neuropharmacol Grp, F-75230 Paris, France
关键词
D O I
10.1038/ncb0304-189
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
During the past fifteen years, a variety of peptides have been characterized for their ability to translocate into live cells. Most are efficient vectors that can internalize hydrophilic cargoes, and so provide a valuable biological (and potentially therapeutic) tool for targeting proteins into cells. Furthermore, translocation of cell-permeable peptides across the plasma membrane and their subsequent access to the cytosol, even when fused to large hydrophilic proteins, is challenging the perception of the plasma membrane as an impermeable barrier.
引用
收藏
页码:189 / 196
页数:8
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