Striatal Local Circuitry: A New Framework for Lateral Inhibition

被引：166
作者：
Burke, Dennis A. [1 ,2 ]
Rotstein, Horacio G. [3 ,4 ,5 ]
Alvarez, Veronica A. [1 ,6 ]
机构：
[1] NIAAA, Lab Neurobiol Compuls Behav, Intramural Res Program, NIH, Bethesda, MD 20892 USA
[2] Brown Univ, Dept Neurosci, Providence, RI 02912 USA
[3] New Jersey Inst Technol, Federated Dept Biol Sci, Newark, NJ 07102 USA
[4] Rutgers State Univ, Newark, NJ 07102 USA
[5] New Jersey Inst Technol, Inst Brain & Neurosci Res, Newark, NJ 07102 USA
[6] NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA
来源：
NEURON | 2017年 / 96卷 / 02期
基金：
美国国家科学基金会;
关键词：
MEDIUM SPINY NEURONS; VENTRAL TEGMENTAL AREA; BASAL GANGLIA CIRCUITRY; FAST-SPIKING INTERNEURONS; TYROSINE-HYDROXYLASE INTERNEURONS; DOPAMINE D2 RECEPTORS; NUCLEUS-ACCUMBENS; PROJECTION NEURONS; CHOLINERGIC INTERNEURONS; GABAERGIC INTERNEURONS;
D O I：
10.1016/j.neuron.2017.09.019
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This Perspective will examine the organization of intrastriatal circuitry, review recent findings in this area, and discuss how the pattern of connectivity between striatal neurons might give rise to the behaviorally observed synergism between the direct/indirect pathway neurons. The emphasis of this Perspective is on the underappreciated role of lateral inhibition between striatal projection cells in controlling neuronal firing and shaping the output of this circuit. We review some classic studies in combination with more recent anatomical and functional findings to lay out a framework for an updated model of the intrastriatal lateral inhibition, where we explore its contribution to the formation of functional units of processing and the integration and filtering of inputs to generate motor patterns and learned behaviors.
引用
收藏
页码：267 / 284
页数：18
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