Cholesterol and mortality in heart failure: The bad gone good?

被引：11

作者：

Fonarow, GC ^{[1
]}

Horwich, TB ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Div Cardiol, Ahmanson UCLA Cardiomyopathy Ctr, Los Angeles, CA 90095 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2003年 / 42卷 / 11期

关键词：

D O I：

10.1016/j.jacc.2003.09.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypercholesterolemia is a well-established risk factor for the development of coronary artery disease (CAD) and for CAD mortality (1). Elevated serum cholesterol levels were also a risk factor for the development of heart failure (HF) in the Framingham study (2). Reduction in serum total cholesterol levels with 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) in patients with CAD has resulted in a reduction in new-onset HF (3). Because CAD is a dominant etiology of HF, it would be reasonable to expect that high cholesterol would also be a risk factor and have deleterious effects for mortality in patients with established HF.

引用

收藏

页码：1941 / 1943

页数：3

相关论文

共 22 条

[11] DEATH RISK IN HEMODIALYSIS-PATIENTS - THE PREDICTIVE VALUE OF COMMONLY MEASURED VARIABLES AND AN EVALUATION OF DEATH RATE DIFFERENCES BETWEEN FACILITIES [J].

LOWRIE, EG ;

LEW, NL .

AMERICAN JOURNAL OF KIDNEY DISEASES, 1990, 15 (05) :458-482

[12]

Maggioni AP, 2001, CURR CONTR TRIALS C, V2, P266

[13] Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections [J].

Netea, MG ;

Demacker, PNM ;

Kullberg, BJ ;

Boerman, OC ;

Verschueren, I ;

Stalenhoef, AFH ;

vanderMeer, JWM .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (06) :1366-1372

[14] 10-YEAR MORTALITY FROM CARDIOVASCULAR-DISEASE IN RELATION TO CHOLESTEROL LEVEL AMONG MEN WITH AND WITHOUT PREEXISTING CARDIOVASCULAR-DISEASE [J].

PEKKANEN, J ;

LINN, S ;

HEISS, G ;

SUCHINDRAN, CM ;

LEON, A ;

RIFKIND, BM ;

TYROLER, HA .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (24) :1700-1707

[15] The endotoxin-lipoprotein hypothesis [J].

Rauchhaus, M ;

Coats, AJS ;

Anker, SD .

LANCET, 2000, 356 (9233) :930-933

[16] The relationship between cholesterol and survival in patients with chronic heart failure [J].

Rauchhaus, M ;

Clark, AL ;

Doehner, W ;

Davos, C ;

Bolger, A ;

Sharma, R ;

Coats, AJS ;

Anker, SD .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (11) :1933-1940

[17]

Rauchhaus M, 2001, J AM COLL CARDIOL, V37, p190A

[18] Inflammatory cytokines and the possible immunological role for lipoproteins in chronic heart failure [J].

Rauchhaus, M ;

Koloczek, V ;

Volk, HD ;

Kemp, M ;

Niebauer, J ;

Francis, DP ;

Coats, AJS ;

Anker, SD .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2000, 76 (2-3) :125-133

[19] Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study [J].

Schatz, IJ ;

Masaki, K ;

Yano, K ;

Chen, R ;

Rodriguez, BL ;

Curb, JD .

LANCET, 2001, 358 (9279) :351-355

[20]

SEGAL R, 2002, EUR J HEART FAIL, V2, pA96