Effects of Flavonoid Supplementation on Nanomaterial-Induced Toxicity: A Meta-Analysis of Preclinical Animal Studies

被引:2
作者
Xie, Dongli [1 ]
Hu, Jianchen [1 ]
Wu, Tong [2 ]
Xu, Wei [3 ]
Meng, Qingyang [4 ]
Cao, Kangli [5 ]
Luo, Xiaogang [1 ]
机构
[1] Soochow Univ, Coll Text & Clothing Engn, Suzhou, Peoples R China
[2] Shanghai Jing Rui Yang Ind Co Ltd, Shanghai, Peoples R China
[3] Shanghai Nutri woods Biotechnol Co Ltd, Shanghai, Peoples R China
[4] Shanghai Pechoin Daily Chem Co Ltd, Shanghai, Peoples R China
[5] Shanghai Inst Spacecraft Equipment, Shanghai, Peoples R China
来源
FRONTIERS IN NUTRITION | 2022年 / 9卷
基金
中国博士后科学基金;
关键词
nanomaterials; oxidative stress; inflammation; flavonoids; meta-analysis; ZINC-OXIDE; INFLAMMATORY RESPONSE; TIO2; NANOPARTICLES; MEDIATED APOPTOSIS; OXIDATIVE STRESS; PROTECTIVE ROLE; QUERCETIN; PATHWAY; DAMAGE; ALPHA;
D O I
10.3389/fnut.2022.929343
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Nanomaterials, widely applied in various fields, are reported to have toxic effects on human beings; thus, preventive or therapeutic measures are urgently needed. Given the anti-inflammatory and antioxidant activities, supplementation with flavonoids that are abundant in the human diet has been suggested as a potential strategy to protect against nanomaterial-induced toxicities. However, the beneficial effects of flavonoids remain inconclusive. In the present study, we performed a meta-analysis to comprehensively explore the roles and mechanisms of flavonoids for animals intoxicated with nanomaterials. Methods: A systematic literature search in PubMed, EMBASE, and Cochrane Library databases was performed up to April 2022. STATA 15.0 software was used for meta-analyses. Results: A total of 26 studies were identified. The results showed that flavonoid supplementation could significantly increase the levels of antioxidative enzymes (superoxide dismutase, catalase, glutathione, glutathione peroxidase, and glutathione-S-transferase), reduce the production of oxidative agents (malonaldehyde) and pro-inflammatory mediators (tumor necrosis factor-alpha, interleukin-6, IL-1 beta, C-reactive protein, immunoglobulin G, nitric oxide, vascular endothelial growth factor, and myeloperoxidase), and alleviate cell apoptosis (manifested by decreases in the mRNA expression levels of pro-apoptotic factors, such as caspase-3, Fas cell surface death receptor, and Bax, and increases in the mRNA expression levels of Bcl2), DNA damage (reductions in tail length and tail DNA%), and nanomaterial-induced injuries of the liver (reduced alanine aminotransferase and aspartate aminotransferase activities), kidney (reduced urea, blood urea nitrogen, creatinine, and uric acid concentration), testis (increased testosterone, sperm motility, 17 beta-hydroxysteroid dehydrogenase type, and reduced sperm abnormalities), and brain (enhanced acetylcholinesterase activities). Most of the results were not changed by subgroup analyses. Conclusion: Our findings suggest that appropriate supplementation of flavonoids may be effective to prevent the occupational detriments resulting from nanomaterial exposure.
引用
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页数:19
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