MECHANISMS IN ENDOCRINOLOGY Autoimmune hypopituitarism: novel mechanistic insights

被引：31
作者：
Takahashi, Yutaka [1 ]
机构：
[1] Kobe Univ, Grad Sch Med, Div Diabet & Endocrinol, Kobe, Hyogo, Japan
来源：
EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2020年 / 182卷 / 04期
关键词：
IGG4-RELATED HYPOPHYSITIS; LYMPHOCYTIC HYPOPHYSITIS; CANCER-IMMUNOTHERAPY; DEFICIENCY; PITUITARY; PATHOGENESIS; ANTIBODIES; ANTIPITUITARY; PANCREATITIS; IPILIMUMAB;
D O I：
10.1530/EJE-19-1051
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hypopituitarism is caused by various insults to the pituitary, such as hypothalamic and pituitary tumors, inflammation, autoimmunity, vascular injury, genetic abnormalities, irradiation, and trauma. Recently, it has been found that autoimmunity to the pituitary involves many pathological conditions associated with specific or non-specific hormone deficiencies in the gland. This review discusses the recent findings on the underlying mechanism of autoimmune hypopituitarism particularly of lymphocytic hypophysitis, IgG4-related hypophysitis, immune checkpoint inhibitor-induced hypophysitis, anti-PIT-1 hypophysitis, and isolated ACTH deficiency.
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收藏
页码：R59 / R66
页数：8
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