The impact of genetic markers on the diagnosis of lung cancer: A current perspective

被引：27

作者：

Chorostowska-Wynimko, Joanna ^{[1
]}

Szpechcinski, Adam ^{[1
]}

机构：

[1] Natl Inst TB & Lung Dis, Lab Mol Diagnost, PL-01138 Warsaw, Poland

来源：

JOURNAL OF THORACIC ONCOLOGY | 2007年 / 2卷 / 11期

关键词：

biomarkers; Bronchoalveolar lavage; exhaled breath condensate; lung cancer; plasma DNA; sputum;

D O I：

10.1097/JTO.0b013e318158eed4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer is the leading worldwide source of cancer-related death. It is acknowledged that prognosis and treatment outcomes in lung cancer might be improved by increasing the effectiveness of early-stage diagnosis. Several recently published studies have produced intriguing results regarding the detection of biomarkers in tumor samples, but also in easily accessible specimens such as sputum, plasma, and exhaled breath condensate. This review presents advances in genetic diagnostics of lung cancer, with particular reference to the clinical usefulness of individual biomarkers, specimens, and methods. The adequacy of their sensitivity and specificity for cancer screening and early detection is discussed in detail.

引用

页码：1044 / 1051

页数：8

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