Merkel cell carcinoma: More deaths but still no pathway to blame

被引：147

作者：

Lemos, Bianca ^{[1
]}

Nghiem, Paul ^{[1
]}

机构：

[1] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2007年 / 127卷 / 09期

关键词：

D O I：

10.1038/sj.jid.5700925

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Merkel cell carcinoma (MCC) is a neuroenclocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous Tcell lymphoma and a mortality (33%) exceeding that of melanoma. Despite this impact, little is known about its biology. Recent studies have shown that Ras/MAP kinase activity is absent and possibly detrimental to this cancer. This makes MCC distinct from other UV-induced skin cancers and highlights the question of what drives this malignancy.

引用

页码：2100 / 2103

页数：4

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