Combined measurement of plasma cell proliferative and apoptotic index in multiple myeloma defines patients with good and poor prognosis

被引：6
作者：
Minarik, Jiri [1 ]
Scudla, Vlastimil [1 ]
Ordeltova, Marta [2 ]
Pika, Tomas [1 ]
Bacovsky, Jaroslav [1 ]
Steinbach, Michael [3 ]
Kumar, Vipin [3 ]
Van Ness, Brian [4 ]
机构：
[1] Univ Hosp Olomouc, Dept Internal Med 3, Olomouc 77520, Czech Republic
[2] Univ Hosp Olomouc, Dept Immunol, Olomouc 77520, Czech Republic
[3] Dept Comp Sci & Engn, Minneapolis, MN USA
[4] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN USA
来源：
LEUKEMIA RESEARCH | 2011年 / 35卷 / 01期
关键词：
Multiple myeloma; Proliferation; Apoptosis; Prognosis; UNDETERMINED SIGNIFICANCE; MONOCLONAL GAMMOPATHIES; LABELING INDEXES; THALIDOMIDE; THERAPY; BORTEZOMIB; DISORDERS; SURVIVAL;
D O I：
10.1016/j.leukres.2010.04.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We assessed plasma cell proliferation (by propidium iodide index, PC-PI) and apoptosis (by annexin-V index PC-AI) for the estimation of overall survival (OS) in multiple myeloma (MM) patients. 181 patients with newly diagnosed MM were assessed, treated using conventional chemotherapy. The values best discriminating patients with poor prognosis were PC-PI >3.0% and PC-AI <4.75%, and for good prognosis PC-PI <= 3.0% and PC-AI >= 4.75%. The median OS was 8 months vs 40 months, p = 0.0002. Our results suggest that combined measurement of plasma cell proliferation and apoptosis creates a unique strong prognostic factor based on growth characteristics of the tumor clone. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：44 / 48
页数：5
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