Current State of Bone Adhesives-Necessities and Hurdles

被引：46

作者：

Boeker, Kai O. ^{[1
]}

Richter, Katharina ^{[2
]}

Jaeckle, Katharina ^{[1
]}

Taheri, Shahed ^{[1
]}

Grunwald, Ingo ^{[3
]}

Borcherding, Kai ^{[2
]}

von Byern, Janek ^{[4
,5
]}

Hartwig, Andreas ^{[2
,6
]}

Wildemann, Britt ^{[7
]}

Schilling, Arndt F. ^{[1
]}

Lehmann, Wolfgang ^{[1
]}

机构：

[1] Univ Med Ctr Goettingen, Dept Trauma Surg Orthopaed & Plast Surg, Robert Koch Str 40, D-37075 Gottingen, Germany

[2] Fraunhofer Inst Mfg Technol & Adv Mat IFAM, Wiener Str 12, D-28359 Bremen, Germany

[3] Hsch Bremen City Univ Appl Sci, Ind & Environm Biol, Neustadtswall 30, D-28199 Bremen, Germany

[4] Ludwig Boltzmann Inst Expt & Clin Traumatol, Austrian Cluster Tissue Regenerat, Donaueschingenstr 13, A-1200 Vienna, Austria

[5] Univ Vienna, Fac Life Sci, Core Facil Cell Imaging & Ultrastruct Res, Althanstr 14, A-1090 Vienna, Austria

[6] Univ Bremen, Dept Biol Chem 2, Leobener Str 3, D-28359 Bremen, Germany

[7] Univ Hosp Jena, Expt Trauma Surg, D-07747 Jena, Germany

来源：

MATERIALS | 2019年 / 12卷 / 23期

关键词：

bone; adhesive; glue; fracture; bioadhesive; osteosynthesis; OSTEOCLASTIC BIORESORPTION; STERNAL CLOSURE; FIBRIN SEALANT; POTENTIAL USE; IN-VITRO; FIXATION; STRENGTH; GLUE; NANOCOMPOSITE; FRACTURE;

D O I：

10.3390/ma12233975

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The vision of gluing two bone fragments with biodegradable and biocompatible adhesives remains highly fascinating and attractive to orthopedic surgeons. Possibly shorter operation times, better stabilization, lower infection rates, and unnecessary removal make this approach very appealing. After 30 years of research in this field, the first adhesive systems are now appearing in scientific reports that may fulfill the comprehensive requirements of bioadhesives for bone. For a successful introduction into clinical application, special requirements of the musculoskeletal system, challenges in the production of a bone adhesive, as well as regulatory hurdles still need to be overcome. In this article, we will give an overview of existing synthetic polymers, biomimetic, and bio-based adhesive approaches, review the regulatory hurdles they face, and discuss perspectives of how bone adhesives could be efficiently introduced into clinical application, including legal regulations.

引用

页数：19

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