Light Control of Cellular Processes by Using Photocaged Abscisic Acid

被引：41

作者：

Wright, Catherine W. ^{[1
]}

Guo, Zhi-Fo ^{[1
]}

Liang, Fu-Sen ^{[1
]}

机构：

[1] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

来源：

CHEMBIOCHEM | 2015年 / 16卷 / 02期

关键词：

abscisic acid; chemically induced dimerization; photocaging; photochemistry; signal transduction; PROTEIN-PROTEIN INTERACTIONS; SPATIOTEMPORAL CONTROL; CHEMICAL INDUCER; CAGED COMPOUNDS; CHEMISTRY; RAC;

D O I：

10.1002/cbic.201402576

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abscisic acid (ABA) was chemically modified with a photocaging group to promote photo-induced protein dimerization. This photocontrolled chemically induced dimerization (CID) method based on caged ABA enables dose-dependent light regulation of cellular processes, including transcription, protein translocation, signal transduction, and cytoskeletal remodeling, without the need to perform extensive protein engineering. Caged ABA can be easily modified to respond to different wavelengths of light. Consequently, this strategy should be applicable to the design of light-regulated protein dimerization systems and potentially be used orthogonally with other light-controlled CID systems.

引用

页码：254 / 261

页数：8

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