The role of cofilin in age-related neuroinflammation

被引：23
作者：
Alsegiani, Amsha S. [1 ]
Shah, Zahoor A. [1 ]
机构：
[1] Univ Toledo, Coll Pharm & Pharmaceut Sci, Dept Med & Biol Chem, 2801 W Bancroft St, Toledo, OH 43606 USA
来源：
NEURAL REGENERATION RESEARCH | 2020年 / 15卷 / 08期
关键词：
aging; astrocyte-activation; cofilin; cofilin inhibitor; cofilin/actin rods; inflammaging; microglial activation; neurogenesis; neuroinflammation; MICROGLIAL ACTIVATION; ACTIN REORGANIZATION; OXIDATIVE STRESS; BRAIN ATROPHY; N-COFILIN; PROTEIN; NEUROGENESIS; TRANSLOCATION; MITOCHONDRIA; ASTROCYTES;
D O I：
10.4103/1673-5374.274330
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active "pro-inflammatory" state, causing chronic low-grade neuroinflammation. Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years, the underlying causes remain unclear. The identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and treatment. This will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the elderly. In this review, we have summarized the morphological and cellular changes in the aging brain, the effects of age-related neuroinflammation, and the potential role of cofilin-1 during neuroinflammation. We also discuss other factors contributing to brain aging and neuroinflammation.
引用
收藏
页码：1451 / 1459
页数：9
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