The simultaneous non-aqueous potentiometric determination of binary mixture of pharmaceutically potent drugs

被引：0
作者：
Patil, Vaishali R. [1 ]
Deohate, Pradip P. [1 ]
机构：
[1] Shri Radhakisan Laxminarayan Toshniwal Coll Sci, Dept Chem, Akola 444001, Maharashtra, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2014年 / 91卷 / 04期
关键词：
Nimesulide-paracetamol; ibuprofen-paracetamol; non-aqueous; potentiometric determination; ACETAMINOPHEN; SALICYLAMIDE; TITRATION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The simultaneous non-aqueous potentiometric determination of binary mixture of pharmaceutically potent drugs by using isopropyl alcohol as the solvent and KOH in isopropyl alcohol as the titrant has been carried out. The two acidic drugs nimesulide-paracetamol and ibuprofen-paracetamol were determined simultaneously in their binary mixtures by non-aqueous differentiating potentiometric titrations. These drug combinations are widely used in medicines. The titrations were carried out using glass and calomel electrode pair. The method was found to be convenient for assay of double component tablets and results obtained are comparable with those obtained by I.P. method.
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页码：647 / 650
页数：4
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