Ketoanalogue-Supplemented Vegetarian Very Low-Protein Diet and CKD Progression

被引:252
作者
Garneata, Liliana [1 ,2 ]
Stancu, Alexandra [2 ]
Dragomir, Diana [2 ]
Stefan, Gabriel [1 ,2 ]
Mircescu, Gabriel [1 ,2 ]
机构
[1] Carol Davila Univ Med & Pharm, Dept Nephrol & Internal Med, Bucharest, Romania
[2] Dr Carol Davila Teaching Hosp Nephrol, Dept Nephrol, Bucharest 010731, Romania
来源
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2016年 / 27卷 / 07期
关键词
CHRONIC KIDNEY-DISEASE; CHRONIC-RENAL-FAILURE; COCKCROFT-GAULT EQUATIONS; BLOOD-PRESSURE CONTROL; AMINO-ACIDS; RESTRICTION; NUTRITION; DIALYSIS; REPLACEMENT; PERFORMANCE;
D O I
10.1681/ASN.2015040369
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Dietary protein restriction may improve determinants of CKD progression. However, the extent of improvement and effect of ketoanalogue supplementation are unclear. We conducted a prospective, randomized, controlled trial of safety and efficacy of ketoanalogue-supplemented vegetarian very low-protein diet (KD) compared with conventional low-protein diet (LPD). Primary end point was RRT initiation or >50% reduction in initial eGFR. Nondiabetic adults with stable eGFR<30 ml/min per 1.73 m(2), proteinuria <1 g/g urinary creatinine, good nutritional status, and good diet compliance entered a run-in phase on LPD. After 3 months, compliant patients were randomized to KD (0.3 g/kg vegetable proteins and 1 cps/5 kg ketoanalogues per day) or continue LPD (0.6 g/kg per day) for 15 months. Only 14% of screened patients patients were randomized, with no differences between groups. Adjusted numbers needed to treat (NNTs; 95% confidence interval) to avoid composite primary end point in intention to treat and per-protocol analyses in one patient were 4.4 (4.2 to 5.1) and 4.0 (3.9 to 4.4), respectively, for patients with eGFR<30 ml/min per 1.73 m(2). Adjusted NNT (95% confidence interval) to avoid dialysis was 22.4 (21.5 to 25.1) for patients with eGFR<30 ml/min per 1.73 m(2) but decreased to 2.7 (2.6 to 3.1) for patients with eGFR<20 ml/min per 1.73 m(2) in intention to treat analysis. Correction of metabolic abnormalities occurred only with KD. Compliance to diet was good, with no changes in nutritional parameters and no adverse reactions. Thus, this KD seems nutritionally safe and could defer dialysis initiation in some patients with CKD.
引用
收藏
页码:2164 / 2176
页数:13
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