Value of imaging findings in predicting post-operative recurrence of desmoid-type fibromatosis

被引:8
作者
Wang, Junyan [1 ,4 ]
Huang, Yijuan [2 ]
Sun, Yanbao [2 ]
Ge, Yuxi [3 ]
Zhang, Minming [1 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 2, Dept Radiol, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China
[2] Jiaxing Univ, Affiliated Hosp 1, Hosp Jiaxing 1, Dept Radiol, Jiaxing 314000, Zhejiang, Peoples R China
[3] Jiangnan Univ, Affiliated Hosp, Dept Radiol, Wuxi 214062, Jiangsu, Peoples R China
[4] Zhejiang Chinese Med Univ, Jiaxing Chinese Med Hosp, Radiol Dept, Jiaxing 314000, Zhejiang, Peoples R China
关键词
desmoid-type fibromatosis; recurrence; imaging findings; sex; tumor maximum diameter; Ki-67; T2 signal ratio; AGGRESSIVE FIBROMATOSIS; SURGICAL RESECTION; SEE POLICY; TUMORS; MANAGEMENT; SERIES;
D O I
10.3892/ol.2019.11129
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Desmoid-type fibromatosis is a rare type of soft-tissue tumor originating from connective tissue of the fascia or aponeurosis, which exhibits aggressive growth, high likelihood of relapse and less frequent distant metastasis. The present study aimed to predict the recurrence rate and time by retrospectively analyzing the clinical data (sex, age and recurrence time), imaging findings [tumor location, maximum diameter, border, computed tomography (CT) enhancement ratio, magnetic resonance enhancement ratio and T2 signal ratio] and pathological features (Ki-67 and microscopic margin) in a total of 102 cases of pathologically confirmed desmoid-type fibromatosis. The risk ratio of each factor was calculated using the Cox proportional hazards regression model and the cumulative recurrence-free survival rate was determined using the Kaplan-Meier method and the log-rank test. The cohort comprised of 73 females and 29 males, with mean age of 32.86 +/- 12.64 years (range, 6-78 years). The 1-year and 2-year recurrence rate was 31 and 54%, respectively. The median age at recurrence was 29 years. Univariate analysis indicated that sex, maximum tumor diameter, CT enhancement ratio and Ki-67 had a significant effect on the recurrence time. Furthermore, multivariate analysis revealed that sex, maximum tumor diameter, Ki-67 and T2 signal ratio were independently associated with the time of recurrence, and the risk ratios were 0.424, 1.100, 1.084 and 1.268, respectively. Therefore, in male patients with a larger maximum tumor diameter, positivity for Ki-67 and a higher T2 signal ratio, desmoid-type fibromatosis was more likely to recur after surgery.
引用
收藏
页码:869 / 875
页数:7
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