A new destruxin as inhibitor of vacuolar-type H+-ATPase of Saccharomyces cerevisiae

被引：23
|
作者：
Vázquez, MJ
Albarrán, MI
Espada, A
Rivera-Sagredo, A
Díez, E
Hueso-Rodríguez, JA
机构：
[1] GlaxoSmithKline, R&D, Ctr Invest Basica, Assay Dev & Compound Profiling Dept, E-28760 Tres Cantos, Madrid, Spain
[2] GlaxoSmithKline, R&D, Ctr Invest Basica, Mol Screening Dept, E-28760 Tres Cantos, Madrid, Spain
[3] GlaxoSmithKline, R&D, Ctr Invest Basica, Cheminformat Dept, E-28760 Tres Cantos, Madrid, Spain
来源：
CHEMISTRY & BIODIVERSITY | 2005年 / 2卷 / 01期
关键词：
D O I：
10.1002/cbdv.200490163
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar-type H+-ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1 - 8, from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D- and 2D-NMR spectroscopy, and MS spectrometry. One of these compounds, 8, a regioisomer of chlorohydrin destruxin E (7), is a new destruxin.
引用
收藏
页码：123 / 130
页数：8
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