Serum S100B levels in children with simple febrile seizures

Purpose: Recent studies have found that S100B is a useful marker for astroglial activation seen in various neurologic disorders. The purpose of this study was to evaluate whether simple febrile seizures (SFS) was associated with an elevation in serum S100B levels. Methods: In this study the samples consisted of 39 patients with SFS ranging from 6 to 36 months of age, and age-matched and sex-matched controls including 30 patients with fever and 30 healthy subjects. Two serum samples were obtained for S100B from the study group at 0-1 h and 6-24 h following seizure. Serum samples were drawn once in the control group. The serum samples were then analyzed using ELISA. Results: In the study group, the mean values of the serum S100B concentrations at 0-1 h and 6-24 h were 32.6 +/- 7.8 pg/ml and 32.1 +/- 5.8 pg/ml, respectively, while the concentrations were 32.1 +/- 8.8 pg/ml and 29.5 +/- 7.8 pg/ml in the control groups. No significant differences were detected in serum S100B levels at 01 h or 6-24 h in the study when compared to the control groups. Conclusions: These results suggest that SFS do not raise serum S100B concentration above the normal range. (C) 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.