The role of microRNAs regulating the expression of matrix metalloproteinases (MMPs) in breast cancer development, progression, and metastasis

被引：56

作者：

Javadian, Mahsa ^{[1
,2
,3
]}

Gharibi, Tohid ^{[1
,2
]}

Shekari, Najibeh ^{[1
,2
]}

Abdollahpour-Alitappeh, Meghdad ^{[4
]}

Mohammadi, Ali ^{[1
,2
]}

Hossieni, Arezoo ^{[1
,2
]}

Mohammadi, Hamed ^{[1
,2
]}

Kazemi, Tohid ^{[1
,2
]}

机构：

[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Dept Immunol, Fac Med, Tabriz 5165683146, Iran

[3] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[4] Larestan Univ Med Sci, Sch Nursing, Dept Nursing, Larestan, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 05期

关键词：

breast cancer; matrix metalloproteinases; metastasis; microRNA; progression; EPITHELIAL-MESENCHYMAL TRANSITION; CELL INVASION; TUMOR-SUPPRESSOR; GROWTH-FACTOR; THERAPEUTIC APPLICATION; PROMOTES PROLIFERATION; COLLAGENASE-3; MMP-13; METALLOPEPTIDASE; 13; PROGNOSTIC MARKERS; TISSUE INHIBITOR;

D O I：

10.1002/jcp.27445

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) regulate several biological and physiological processes in mammalian cells, including cellular proliferation, differentiation, apoptosis, and metabolism. Recent studies have confirmed the alteration of them during the cancer development. Matrix metalloproteinases (MMPs), belonging to the large family of proteases, have also been demonstrated to play crucial roles in tissue remodeling, and to support cancer progression and metastasis. There are several known miRNAs which regulate the MMP family and their expression. The expression profiles of miRNAs involved in MMP regulation, change during cancer progression, and metastasis. The present review focuses on important miRNAs capable of targeting MMPs through direct and indirect interactions during the breast cancer development, progression, and metastasis.

引用

页码：5399 / 5412

页数：14

共 182 条

[11] MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer [J].