Identifying Progression in Multiple Sclerosis: New Perspectives

被引：79
作者：
Filippi, Massimo [1 ,2 ,3 ,4 ]
Preziosa, Paolo [1 ,2 ]
Langdon, Dawn [5 ]
Lassmann, Hans [6 ]
Paul, Friedemann [7 ,8 ,9 ]
Rovira, Alex [10 ,11 ]
Schoonheim, Menno M. [12 ]
Solari, Alessandra [13 ]
Stankoff, Bruno [14 ]
Rocca, Maria A. [1 ,2 ]
机构：
[1] IRCCS San Raffaele Sci Inst, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, Milan, Italy
[2] IRCCS San Raffaele Sci Inst, Neurol Unit, Milan, Italy
[3] IRCCS San Raffaele Sci Inst, Neurophysiol Unit, Milan, Italy
[4] Univ Vita Salute San Raffaele, Milan, Italy
[5] Royal Holloway Univ London, London, England
[6] Med Univ Vienna, Ctr Brain Res, Vienna, Austria
[7] Max Delbrueck Ctr Mol Med, NeuroCure Clin Res Ctr, Berlin, Germany
[8] Max Delbrueck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany
[9] Charite Univ Med Berlin, Berlin, Germany
[10] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Dept Radiol, Neuroradiol Sect, Barcelona, Spain
[11] Autonomous Univ Barcelona, Res Inst, Barcelona, Spain
[12] Vrije Univ Amsterdam, Amsterdam Univ, Med Ctr,Amsterdam Neurosci, Dept Anat & Neurosci,Multiple Sclerosis Ctr Amste, Amsterdam, Netherlands
[13] Fdn IRCCS Ist Neurol Carlo Besta, Unit Neuroepidemiol, Milan, Italy
[14] Sorbonne Univ, AP HP, Paris Brain Inst ICM, Inst Cerveau,Inserm,CNRS, Paris, France
来源：
ANNALS OF NEUROLOGY | 2020年 / 88卷 / 03期
关键词：
GRAY-MATTER ATROPHY; PATIENT-REPORTED OUTCOMES; LONG-TERM OUTCOMES; QUALITY-OF-LIFE; DISABILITY PROGRESSION; NEUROFILAMENT LIGHT; RELAPSE-ONSET; LESIONS; DAMAGE; MRI;
D O I：
10.1002/ana.25808
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The identification of progression in multiple sclerosis is typically retrospective. Given the profound burden of progressive multiple sclerosis, and the recent development of effective treatments for these patients, there is a need to establish measures capable of identifying progressive multiple sclerosis early in the disease course. Starting from recent pathological findings, this review assesses the state of the art of potential measures able to predict progressive multiple sclerosis. Future promising biomarkers that might shed light on mechanisms of progression are also discussed. Finally, expansion of the concept of progressive multiple sclerosis, by including an assessment of cognition, patient-reported outcomes, and comorbidities, is considered. ANN NEUROL 2020
引用
收藏
页码：438 / 452
页数：15
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