Acid-labile δ-ketal-β-hydroxy esters by asymmetric hydrogenation of corresponding δ-ketal-β-keto esters in the presence of CaCO3

被引：19

作者：

Fan, Weizheng ^{[1
]}

Li, Wanfang ^{[1
]}

Ma, Xin ^{[1
]}

Tao, Xiaoming ^{[1
]}

Li, Xiaoming ^{[1
]}

Yao, Ying ^{[1
]}

Xie, Xiaomin ^{[1
]}

Zhang, Zhaoguo ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

[2] Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 35期

基金：

中国国家自然科学基金;

关键词：

HIGHLY ENANTIOSELECTIVE HYDROGENATION; RU-BINAP COMPLEX; PRACTICAL SYNTHESIS; LIGANDS; DERIVATIVES; COMPACTIN; SOLVENT; ANALOGS;

D O I：

10.1039/c2cc31002c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of acid-labile, optically pure epsilon-substituted delta-ketal-beta-hydroxy esters were obtained by a Ru-SunPhos catalyzed asymmetric hydrogenation of the corresponding epsilon-substituted delta-ketal-beta-keto esters. CaCO3 played a dual role in the hydrogenation reaction-removing the acid generated during the formation of the catalyst and maintaining the activity of the catalyst.

引用

页码：4247 / 4249

页数：3

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