The impact of the Uighur medicine abnormal savda munziq on antitumor and antioxidant activity in a S180 and Ehrlich ascites carcinoma mouse tumor model

被引:13
|
作者
Aikemu, Ainiwaer [2 ,3 ]
Yusup, Abdiryim [3 ]
Umar, Anwar [1 ,4 ]
Berke, Benedicte [1 ,4 ]
Moore, Nicholas [1 ,4 ]
Upur, Halmurat [1 ,3 ]
机构
[1] Xinjiang Med Univ, Dept Pharmacol, Urumqi 830011, Xinjiang, Peoples R China
[2] Xinjiang Med Univ, Dept Drug Anal, Urumqi 830011, Xinjiang, Peoples R China
[3] Xinjiang Med Univ, Dept Tradit Uighur Med, Urumqi 830011, Xinjiang, Peoples R China
[4] Univ Bordeaux 2, Dept Pharmacol, F-33076 Bordeaux, France
关键词
Abnormal savda munziq; antioxidant; antitumor; LIPID-PEROXIDATION; ENZYME-ACTIVITIES; HYPOXIA; TOLERANCE; ERYTHROPOIETIN; EXTRACT; STRESS; MUSHIL; CELLS;
D O I
10.4103/0973-1296.96568
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Aim: This study was designed to study the antitumor and antioxidant activity of Uighur medicine abnormal savda munziq (ASMq) in the S180 and Ehrlich ascites carcinoma mice tumor model. Materials and Methods: The serum levels of superoxide dismutase (SOD), malonaldehyde (MDA), and glutathione-catalase (GSH-PX) were analyzed, and the mice were also subjected to a hypoxia tolerance test. Their climbing ability was also analyzed. Results: The findings of the study revealed that ASMq-treatment leads to an increase in blood serum SOD and GSH-PX levels but a decrease in blood serum MDA levels. Moreover, ASMq-treatment enhanced the survival time of mice maintained under hypoxic conditions and improved their mice climbing ability. Conclusions: The results of this study indicate that ASMq has obvious antitumor and antioxidative effects.
引用
收藏
页码:141 / 148
页数:8
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