A novel platform for modeling oxidative catalysis in non-heme iron oxygenases with unprecedented efficiency

被引：121

作者：

Company, Anna ^{[1
]}

Gomez, Laura ^{[1
]}

Fontrodona, Xavier ^{[2
]}

Ribas, Xavi ^{[1
]}

Costas, Miquel ^{[1
]}

机构：

[1] Univ Girona, Dept Quim, Girona 17071, Spain

[2] Univ Girona, Serv Tecn Recerca, Girona 17071, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 19期

关键词：

bioinorganic chemistry; enzyme catalysis; model compounds; non-heme oxygenases; oxidation;

D O I：

10.1002/chem.200800724

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study was conducted to demonstrate a number of non-heme iron complexes, based on the methylpyridine derivatized triazacyclononane (TACN) backbone. It was found that these iron complexes show significant efficiency in the stereospecific oxidation of alkanes with H2O2, bypassing the latest oxidations catalyzed by TPA and BPMEN complexes. It was also demonstrated that the type of substitution on the N atoms of the triazamacrocyle and on the pyridine ring are key tools, to control the selectivity of the iron complexes in catalytic alkane and alkene oxidation reactions. It was also shown that this structural control of the catalytic selectivity in bioinspired oxidation reactions makes the iron complexes an efficient platform, to mimic iron dependent oxygenase reactivity.

引用

页码：5727 / 5731

页数：5

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