Hydroxychloroquine and Azithromycin as Treatments for COVID-19

被引:0
|
作者
Ohe, Masashi [1 ]
Furuya, Ken [1 ]
Goudarzi, Houman [2 ,3 ]
机构
[1] JCHO Hokkaido Hosp, Dept Internal Med, Sapporo, Hokkaido, Japan
[2] Hokkaido Univ, Fac Med, Dept Resp Med, Sapporo, Hokkaido, Japan
[3] Hokkaido Univ, Grad Fac Med, Sapporo, Hokkaido, Japan
来源
GAZI MEDICAL JOURNAL | 2020年 / 31卷 / 2A期
关键词
COVID-19; SARS-CoV-2; Hydroxychloroquine; Macrolide; Azithromycin;
D O I
10.12996/gmj.2020.82
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak that originated in late 2019 and continues to spread as of 2020 is taking a severe toll on human health and has been acknowledged as a worldwide pandemic. There have been no readily available vaccines or drugs that have been approved to combat the disease (COVID-19) as of yet. Chloroquine (CQ), a drug well-known for its effectiveness in treating malarial and autoimmune disease such as rheumatoid arthritis and lupus erythematosus, has exhibited a promising inhibitory effect for SARS-CoV-2. Hydroxychloroquine (HCQ), a more tolerable derivative of CQ, has also been shown to display potent activity against SARS-CoV-2. Macrolides (MACs) such as erythromycin, clarithromycin, and azithromycin (AZM) not only have the potential for anti-bacterial activity but also have immunomodulatory effects. Lately, the anti-viral effects of MACs have attracted considerable attention. Very recently, HCQ in combination with AZM treatment was reported to be effective for mild form of COVID-19. Because mild form of COVID-19 may take a turn for the worse, resulting in acute respiratory distress syndrome, or mild COVID-19 patients may infect surrounding people with COVID-19, patients should be treated with HCQ in combination with AZM.
引用
收藏
页码:337 / 338
页数:2
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