Management of autoimmune diseases after haematopoietic stem cell transplantation

被引：71

作者：

Holbro, Andreas ^{[2
,3
]}

Abinun, Mario ^{[4
,5
]}

Daikeler, Thomas ^{[1
]}

机构：

[1] Univ Basel Hosp, Clin Rheumatol, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Clin Haematol, CH-4031 Basel, Switzerland

[3] Univ Basel Hosp, Med Outpatient Clin, CH-4031 Basel, Switzerland

[4] Great N Childrens Hosp, Royal Victoria Infirm, Dept Paediat Immunol, Newcastle Upon Tyne, Tyne & Wear, England

[5] Univ Newcastle, Inst Cellular Med, Sch Med, Newcastle Upon Tyne, Tyne & Wear, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2012年 / 157卷 / 03期

关键词：

autoimmune disease; transplantation; allogeneic; cord blood; management; BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; CORD BLOOD TRANSPLANTATION; IMMUNE HEMOLYTIC-ANEMIA; REGULATORY T-CELLS; PHASE-I TRIAL; MYASTHENIA-GRAVIS; SYSTEMIC-SCLEROSIS; THROMBOCYTOPENIC PURPURA; THYROID-DYSFUNCTION;

D O I：

10.1111/j.1365-2141.2012.09070.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) is an option for the treatment of malignant and non-malignant diseases, including the severe autoimmune diseases. Intriguingly, the new autoimmunity developing after transplantation is a constantly recognized phenomenon, which has to be differentiated from original disease relapse, toxicity, infection and graft-versus-host disease. The reported autoimmune diseases occurring in this setting are mainly antibody-associated and organ-specific, with scarce evidence in support for specific treatment options. This review focuses on current concepts on the pathogenesis, the available data on incidence, risk factors, manifestations and treatment of post-HSCT autoimmune diseases.

引用

页码：281 / 290

页数：10

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