Suicide gene therapy for brain tumor by means of adeno-associated virus (AAV) vector

被引：0

作者：

Yoshida, J

Mizuno, M

机构：

来源：

11TH INTERNATIONAL CONGRESS OF NEUROLOGICAL SURGERY, VOLS 1 AND 2 | 1997年

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暂无

中图分类号：

R74 [神经病学与精神病学];

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摘要：

We investigated adeno-associated virus (AAV) vector-based suicide gene therapy toward experimental human glioma transplanted in the brain of nude mice by intratumoral injectioin of AAVvector carrying herpes simplex thymidine kinase (HS-tk) and intraperitoneal administration of ganciclovir (GCV). Single treatment of HS-tk/GCV significantly inhibited the growth of the tumor and complete regression can be obtained by its multiple treatments.

引用

页码：407 / 409

页数：3