Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine

被引：50

作者：

Vander Veen, Ryan L. ^{[1
,2
,3
]}

Loynachand, Alan T. ^{[4
]}

Mogler, Mark A. ^{[1
,3
]}

Russell, Brandon J. ^{[2
]}

Harris, D. L. Hank ^{[1
,5
,6
]}

Kamrud, Kurt I. ^{[1
,5
]}

机构：

[1] Harrisvaccines Inc, Ames, IA 50010 USA

[2] Iowa State Univ, Immunobiol Program, Ames, IA 50011 USA

[3] Iowa State Univ, Coll Vet Med, Dept Vet Microbiol & Prevent Med, Ames, IA 50011 USA

[4] Univ Kentucky, Vet Diagnost Lab, Lexington, KY 40511 USA

[5] Iowa State Univ, Coll Agr, Dept Anim Sci, Ames, IA 50011 USA

[6] Coll Vet Med, Dept Vet Diagnost & Prod Anim Med, Ames, IA 50011 USA

来源：

VACCINE | 2012年 / 30卷 / 11期

关键词：

Alphavirus replicon; Swine influenza virus (SIV); Vaccine; Hemagglutinin (HA); Swine; Safety; NEUTRALIZING ANTIBODIES; PRECLINICAL EVALUATION; A VIRUSES; IN-VITRO; EXPRESSION; PIGS; SYSTEM; PARTICLES; HUMANS; VECTOR;

D O I：

10.1016/j.vaccine.2012.01.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A single-cycle, propagation-defective replicon particle (RP) vaccine expressing a swine influenza virus hemagglutinin (HA) gene was constructed and evaluated in several different animal studies. Studies done in both the intended host (pigs) and non-host (mice) species demonstrated that the RP vaccine is not shed or spread by vaccinated animals to comingled cohorts, nor does it revert to virulence following vaccination. In addition, vaccinated pigs develop both specific humoral and IFN-gamma immune responses, and young pigs are protected against homologous influenza virus challenge. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1944 / 1950

页数：7

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