Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

被引：594

作者：

Sonnenberg, Gregory F. ^{[1
,2
]}

Monticelli, Laurel A. ^{[1
,2
]}

Alenghat, Theresa ^{[1
,2
]}

Fung, Thomas C. ^{[1
,2
]}

Hutnick, Natalie A. ^{[3
]}

Kunisawa, Jun ^{[4
,5
]}

Shibata, Naoko ^{[4
,5
]}

Grunberg, Stephanie ^{[1
,2
]}

Sinha, Rohini ^{[1
,2
]}

Zahm, Adam M. ^{[6
]}

Tardif, Melanie R. ^{[7
]}

Sathaliyawala, Taheri ^{[8
,9
]}

Kubota, Masaru ^{[8
,9
]}

Farber, Donna L. ^{[8
,9
]}

Collman, Ronald G. ^{[10
]}

Shaked, Abraham ^{[11
]}

Fouser, Lynette A. ^{[12
]}

Weiner, David B. ^{[3
]}

Tessier, Philippe A. ^{[7
]}

Friedman, Joshua R. ^{[6
]}

Kiyono, Hiroshi ^{[4
,5
,13
]}

Bushman, Frederic D. ^{[1
,2
]}

Chang, Kyong-Mi ^{[10
,14
]}

Artis, David ^{[1
,2
,15
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Inst Immunol, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[4] Univ Tokyo, Inst Med Sci, Div Mucosal Immunol, Tokyo 1088639, Japan

[5] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Chiba 2778562, Japan

[6] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat,Div Gastroenterol Hepatol & Nutr, Philadelphia, PA 19104 USA

[7] Univ Laval, Fac Med, CHU Laval, Ctr Rech Infectiol, Quebec City, PQ G1K 7P4, Canada

[8] Columbia Univ, Med Ctr, Dept Surg, New York, NY 10032 USA

[9] Columbia Univ, Med Ctr, Columbia Ctr Translat Immunol, New York, NY 10032 USA

[10] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA

[11] Univ Penn, Dept Surg, Philadelphia, PA 19104 USA

[12] Pfizer Worldwide R&D, Inflammat & Immunol Res Unit, Biotherapeut Res & Dev, Cambridge, MA 02140 USA

[13] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Tokyo 1020075, Japan

[14] Philadelphia VA Med Ctr, Philadelphia, PA 19104 USA

[15] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2012年 / 336卷 / 6086期

关键词：

ALCALIGENES-XYLOSOXIDANS; INTESTINAL BACTERIA; HOST-DEFENSE; MICROBIOTA; ACHROMOBACTER; INFLAMMATION; HOMEOSTASIS; IDENTIFICATION; IMMUNITY; SYSTEM;

D O I：

10.1126/science.1222551

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mammalian intestinal tract is colonized by trillions of beneficial commensal bacteria that are anatomically restricted to specific niches. However, the mechanisms that regulate anatomical containment remain unclear. Here, we show that interleukin-22 (IL-22)-producing innate lymphoid cells (ILCs) are present in intestinal tissues of healthy mammals. Depletion of ILCs resulted in peripheral dissemination of commensal bacteria and systemic inflammation, which was prevented by administration of IL-22. Disseminating bacteria were identified as Alcaligenes species originating from host lymphoid tissues. Alcaligenes was sufficient to promote systemic inflammation after ILC depletion in mice, and Alcaligenes-specific systemic immune responses were associated with Crohn's disease and progressive hepatitis C virus infection in patients. Collectively, these data indicate that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases.

引用

页码：1321 / 1325

页数：5

共 29 条

[1] Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients with cancer (1989-2003) [J].

Aisenberg, G ;

Rolston, KV ;

Safdar, A .

CANCER, 2004, 101 (09) :2134-2140

[2] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[3] Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa [J].

Bergstrom, Kirk S. B. ;

Kissoon-Singh, Vanessa ;

Gibson, Deanna L. ;

Ma, Caixia ;

Montero, Marinieve ;

Sham, Ho Pan ;

Ryz, Natasha ;

Huang, Tina ;

Velcich, Anna ;

Finlay, B. Brett ;

Chadee, Kris ;

Vallance, Bruce A. .

PLOS PATHOGENS, 2010, 6 (05)

[4] Microbial Translocation Across the GI Tract [J].

Brenchley, Jason M. ;

Douek, Daniel C. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30, 2012, 30 :149-173

[5]

Busse HJ, 2006, PROKARYOTES: A HANDBOOK ON THE BIOLOGY OF BACTERIA, VOL 5, THIRD EDITION, P675, DOI 10.1007/0-387-30745-1_28

[6] Achromobacter xylosoxidans bacteremia: Report of four cases and review of the literature [J].

Duggan, JM ;

Goldstein, SJ ;

Chenoweth, CE ;

Kauffman, CA ;

Bradley, SF .

CLINICAL INFECTIOUS DISEASES, 1996, 23 (03) :569-576

[7] Meningitis caused by Alcaligenes xylosoxidans in a patient with HIV/AIDS [J].

Espinoza-Gomez, F. ;

Newton-Sanchez, O. A. ;

Melnikov, V. ;

Virgen-Gonzalez, O. ;

Unrau, J. .

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, 2007, 11 (06) :603-604

[8] Evaluation of the VITEK 2 system for rapid identification of medically relevant gram-negative rods [J].

Funke, G ;

Monnet, D ;

deBernardis, C ;

von Graevenitz, A ;

Freney, J .

JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (07) :1948-1952

[9] Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation [J].

Hill, David A. ;

Siracusa, Mark C. ;

Abt, Michael C. ;

Kim, Brian S. ;

Kobuley, Dmytro ;

Kubo, Masato ;

Kambayashi, Taku ;

LaRosa, David F. ;

Renner, Ellen D. ;

Orange, Jordan S. ;

Bushman, Frederic D. ;

Artis, David .

NATURE MEDICINE, 2012, 18 (04) :538-546

[10] Intestinal Bacteria and the Regulation of Immune Cell Homeostasis [J].

Hill, David A. ;

Artis, David .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 28, 2010, 28 :623-667

← 1 2 3 →