Translational mini-review series on the immunogenetics of gut disease: Immunogenetics of coeliac disease

被引：39

作者：

Dubois, P. C. ^{[1
]}

van Heel, D. A. ^{[1
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Inst Cell & Mol Sci, London E1 2AT, England

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2008年 / 153卷 / 02期

基金：

英国医学研究理事会;

关键词：

autoimmune; coeliac; genetics; immunogenetics; genome-wide association;

D O I：

10.1111/j.1365-2249.2008.03704.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent advances in immunological and genetic research in coeliac disease provide new and complementary insights into the immune response driving this chronic intestinal inflammatory disorder. Both approaches confirm the central importance of T cell-mediated immune responses to disease pathogenesis and have further begun to highlight other relevant components of the mucosal immune system, including innate immunity and the control of lymphocyte trafficking to the mucosa. In the last year, the first genome wide association study in celiac disease led to the identification of multiple new risk variants. These risk regions implicate genes involved in the immune system. Overlap with autoimmune diseases is striking with several of these regions being shown to confer susceptibility to other chronic immune-mediated diseases, particularly type 1 diabetes.

引用

页码：162 / 173

页数：12

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