One-pot self-assembly of mesoporous silica nanoparticle-based pH-responsive anti-cancer nano drug delivery system

被引:35
作者
He, Qianjun [1 ]
Gao, Yu [2 ]
Zhang, Lingxia [1 ]
Bu, Wenbo [1 ]
Chen, Hangrong [1 ]
Li, Yaping [2 ]
Shi, Jianlin [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
关键词
SIZE; GLYCOPROTEIN; RELEASE; POLYMER; CELLS;
D O I
10.1039/c1jm13598h
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A mesoporous silica nanoparticle (MSN)-based pH-responsive nano drug delivery system (hydrophobic drugs@micelles@MSNs) is constructed by a one-pot self-assembly strategy, exhibiting improved drug efficacy against both drug-resistant and drug-sensitive cancer cells.
引用
收藏
页码:15190 / 15192
页数:3
相关论文
共 26 条
  • [1] Organic-Inorganic Nanospheres with Responsive Molecular Gates for Drug Storage and Release
    Corma, Avelino
    Diaz, Urbano
    Arrrica, Maria
    Fernandez, Eduardo
    Ortega, Ilida
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (34) : 6247 - 6250
  • [2] Preparation, characterization, and application of multistimuli-responsive microspheres with fluorescence-labeled magnetic cores and thermoresponsive shells
    Deng, YH
    Wang, CC
    Shen, XZ
    Yang, WL
    An, L
    Gao, H
    Fu, SK
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (20) : 6006 - 6013
  • [3] Magnetically responsive ordered mesoporous materials: A burgeoning family of functional composite nanomaterials
    Deng, Yonghui
    Cai, Yue
    Sun, Zhenkun
    Zhao, Dongyuan
    [J]. CHEMICAL PHYSICS LETTERS, 2011, 510 (1-3) : 1 - 13
  • [4] In situ investigations on cetyltrimethyl ammonium surfactant/silicate systems, precursors of organized mesoporous MCM-41-type siliceous materials
    Frasch, J
    Lebeau, B
    Soulard, M
    Patarin, J
    Zana, R
    [J]. LANGMUIR, 2000, 16 (23) : 9049 - 9057
  • [5] P-glycoprotein - A mediator of multidrug resistance in tumour cells
    Germann, UA
    [J]. EUROPEAN JOURNAL OF CANCER, 1996, 32A (06) : 927 - 944
  • [6] ARE CANCER-CELLS ACIDIC
    GRIFFITHS, JR
    [J]. BRITISH JOURNAL OF CANCER, 1991, 64 (03) : 425 - 427
  • [7] Synthesis of oxygen-deficient luminescent mesoporous silica nanoparticles for synchronous drug delivery and imaging
    He, Qianjun
    Shi, Jianlin
    Cui, Xiangzhi
    Wei, Chenyang
    Zhang, Lingxia
    Wu, Wei
    Bu, Wenbo
    Chen, Hangrong
    Wu, Huixia
    [J]. CHEMICAL COMMUNICATIONS, 2011, 47 (28) : 7947 - 7949
  • [8] Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility
    He, Qianjun
    Shi, Jianlin
    [J]. JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (16) : 5845 - 5855
  • [9] In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation
    He, Qianjun
    Zhang, Zhiwen
    Gao, Fang
    Li, Yaping
    Shi, Jianlin
    [J]. SMALL, 2011, 7 (02) : 271 - 280
  • [10] Size-controlled synthesis of monodispersed mesoporous silica nano-spheres under a neutral condition
    He, Qianjun
    Cui, Xiangzhi
    Cui, Fangming
    Guo, Limin
    Shi, Jianlin
    [J]. MICROPOROUS AND MESOPOROUS MATERIALS, 2009, 117 (03) : 609 - 616