Clinical and Virologic Response to Episodic Acyclovir for Genital Ulcers Among HIV-1 Seronegative, Herpes Simplex Virus Type 2 Seropositive African Women: A Randomized, Placebo-Controlled Trial

被引：6

作者：

Baeten, Jared M. ^{[1
,2
,3
]}

Reid, Stewart E. ^{[4
,5
]}

Delany-Moretlwe, Sinead ^{[6
]}

Hughes, James P. ^{[7
]}

Wang, Richard S. ^{[1
]}

Wilcox, Ellen ^{[1
]}

Limbada, Mohammed ^{[5
]}

Akpomiemie, Godspower ^{[6
]}

Corey, Lawrence ^{[2
,8
,9
]}

Wald, Anna ^{[2
,3
,8
,9
]}

Celum, Connie ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Dept Global Hlth, Seattle, WA 98104 USA

[2] Univ Washington, Dept Med, Seattle, WA 98104 USA

[3] Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA

[4] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[5] Ctr Infect Dis Res Zambia, Lusaka, Zambia

[6] Univ Witwatersrand, Sch Clin Med, Wits Inst Reprod Hlth & HIV, Johannesburg, South Africa

[7] Univ Washington, Dept Biostat, Seattle, WA 98104 USA

[8] Univ Washington, Dept Lab Med, Seattle, WA 98104 USA

[9] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA

来源：

SEXUALLY TRANSMITTED DISEASES | 2012年 / 39卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ORAL ACYCLOVIR; DOUBLE-BLIND; SUPPRESSION; MEN; VALACYCLOVIR; ACQUISITION; INFECTION; EFFICACY; IMPACT; RNA;

D O I：

10.1097/OLQ.0b013e31823b50c6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In a randomized trial among African women with recurrent genital herpes, episodic acyclovir therapy resulted in modestly greater likelihood of lesion healing (hazard ratio [HR] = 1.48, P = 0.098; mean, 5.1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries (ClinicalTrials.gov registration NCT00808405).

引用

页码：21 / 24

页数：4

共 15 条

[1] Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial
Mayaud, Philippe
LeGoff, Jerome
Weiss, Helen A.
Gresenguet, Gerard
Nzambi, Khonde
Bouhlal, Hicham
Frost, Eric
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Malkin, Jean-Elie
Hayes, Richard J.
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Belec, Laurent
JOURNAL OF INFECTIOUS DISEASES, 2009, 200 (02): : 216 - 226
[2] Herpes Simplex Virus Type 2, Genital Ulcers and HIV-1 Disease Progression in Postpartum Women
Roxby, Alison C.
Drake, Alison L.
John-Stewart, Grace
Brown, Elizabeth R.
Matemo, Daniel
Otieno, Phelgona A.
Farquhar, Carey
PLOS ONE, 2011, 6 (05):
[3] Daily Acyclovir to Decrease Herpes Simplex Virus Type 2 (HSV-2) Transmission from HSV-2/HIV-1 Coinfected Persons: A Randomized Controlled Trial
Mujugira, Andrew
Magaret, Amalia S.
Celum, Connie
Baeten, Jared M.
Lingappa, Jairam R.
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de Bruyn, Guy
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[4] Effect of Acyclovir on HIV-1 Set Point among Herpes Simplex Virus Type 2-Seropositive Persons during Early HIV-1 Infection
Kim, H. Nina
Wang, Jing
Hughes, James
Coombs, Robert
Sanchez, Jorge
Reid, Stewart
Delany-Moretlwe, Sinead
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JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (05): : 734 - 738
[5] Acyclovir Achieves a Lower Concentration in African HIV-Seronegative, Herpes Simplex Virus 2-Seropositive Women than in Non-African Populations
Lu, Yanhui
Celum, Connie
Wald, Anna
Baeten, Jared M.
Cowan, Frances
Delany-Moretlwe, Sinead
Reid, Stewart E.
Hughes, James P.
Wilcox, Ellen
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Hendrix, Craig W.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (05) : 2777 - 2779
[6] Impact of aciclovir on genital and plasma HIV-1 RNA in HSV-2/HIV-1 co-infected women: a randomized placebo-controlled trial in South Africa
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AIDS, 2009, 23 (04) : 461 - 469
[7] Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial
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Bassit, Leda C.
Kauffman, Robert C.
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CLINICAL INFECTIOUS DISEASES, 2015, 60 (11) : 1708 - 1714
[8] Effect of daily aciclovir on HIV disease progression in individuals in Rakai, Uganda, co-infected with HIV-1 and herpes simplex virus type 2: a randomised, double-blind placebo-controlled trial
Reynolds, Steven J.
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LANCET INFECTIOUS DISEASES, 2012, 12 (06): : 441 - 448
[9] A prospective study of risk factors for herpes simplex virus type 2 acquisition among high-risk HIV-1 seronegative women in Kenya
Chohan, V.
Baeten, J. M.
Benki, S.
Graham, S. M.
Lavreys, L.
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SEXUALLY TRANSMITTED INFECTIONS, 2009, 85 (07) : 489 - 492
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Forhan, S. E.
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Leelawiwat, W.
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INTERNATIONAL JOURNAL OF STD & AIDS, 2012, 23 (08) : 560 - 564

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