Serological and molecular evidence that human herpesvirus 8 is endemic among Amerindians in French Guiana

被引：34
作者：
Kazanji, M
Dussart, P
Duprez, R
Tortevoye, P
Pouliquen, JF
Vandekerkhove, J
Couppié, P
Morvan, J
Talarmin, A
Gessain, A
机构：
[1] Inst Pasteur, Lab Retrovirol, Cayenne, French Guiana
[2] Inst Pasteur, Virol Lab, Cayenne, French Guiana
[3] Ctr Hosp Gen Cayenne, Cayenne, French Guiana
[4] Inst Pasteur, Dept Ecosyst & Epidemiol Malad Infect, Unite Epidemiol & Physiopathol Virus Oncogenes, F-75724 Paris, France
来源：
JOURNAL OF INFECTIOUS DISEASES | 2005年 / 192卷 / 09期
关键词：
D O I：
10.1086/491744
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We evaluated the presence of human herpesvirus 8 (HHV-8) infection among groups of Amerindians in French Guiana. The overall prevalence of antibodies against lytic HHV-8 antigens was 23.0% (180/781), increasing from 18.4% in children <6 years old to similar to 30% in older persons (>45 years). Seroprevalence was higher in Amerindians living in remote localities than it was in those living in the coastal region. Analysis of a 725 - base pair fragment of the K1 gene amplified from DNA from a Wayampi Amerindian showed that the virus belonged to molecular subtype E, which has hitherto been found in only a few Amerindians in Brazil and Ecuador.
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页码：1525 / 1529
页数：5
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