All the light that we can see: a new era in miniaturized microscopy

被引：110

作者：

Aharoni, Daniel ^{[1
]}

Khakh, Baljit S. ^{[2
,3
]}

Silva, Alcino J. ^{[4
,5
,6
]}

Golshani, Peyman ^{[1
,6
]}

机构：

[1] Univ Calif Los Angeles, Dept Neurol, Integrat Ctr Learning & Memory, Brain Res Inst, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Brain Res Inst, Integrat Ctr Learning & Memory, Dept Neurobiol, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Brain Res Inst, Integrat Ctr Learning & Memory, Dept Psychol, Los Angeles, CA 90024 USA

[6] Univ Calif Los Angeles, Brain Res Inst, Integrat Ctr Learning & Memory, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

来源：

NATURE METHODS | 2019年 / 16卷 / 01期

关键词：

2-PHOTON MICROSCOPE; NEURAL ACTIVITY; CAMERA; MAZE; MICE;

D O I：

10.1038/s41592-018-0266-x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

One major challenge in neuroscience is to uncover how defined neural circuits in the brain encode, store, modify, and retrieve information. Meeting this challenge comprehensively requires tools capable of recording and manipulating the activity of intact neural networks in naturally behaving animals. Head-mounted miniature microscopes are emerging as a key tool to address this challenge. Here we discuss recent work leading to the miniaturization of neural imaging tools, the current state of the art in this field, and the importance and necessity of open-source options. We finish with a discussion on what the future may hold for miniature microscopy.

引用

页码：11 / 13

页数：4

共 31 条

[1] A shared neural ensemble links distinct contextual memories encoded close in time [J].