Dissecting the Genetics of Osteoporosis using Systems Approaches

被引：34
作者：
Al-Barghouthi, Basel M. [1 ]
Farber, Charles R. [1 ,2 ]
机构：
[1] Univ Virginia, Dept Biochem & Mol Genet, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA
[2] Univ Virginia, Dept Publ Hlth Sci, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA
来源：
TRENDS IN GENETICS | 2019年 / 35卷 / 01期
基金：
美国国家卫生研究院;
关键词：
GENOME-WIDE ASSOCIATION; BONE-MINERAL DENSITY; COMPLEX TRAITS; THERAPEUTIC TARGETS; NETWORK ANALYSIS; GWAS; VARIANTS; DISEASE; GENES; LOCI;
D O I：
10.1016/j.tig.2018.10.004
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Osteoporosis is a condition characterized by low bone mineral density (BMD) and an increased risk of fracture. Traits contributing to osteoporotic fracture are highly heritable, indicating that a comprehensive understanding of bone requires a thorough understanding of the genetic basis of bone traits. Towards this goal, genome-wide association studies (GWASs) have identified over 500 loci associated with bone traits. However, few of the responsible genes have been identified, and little is known of how these genes work together to influence systems-level bone function. In this review, we describe how systems genetics approaches can be used to fill these knowledge gaps.
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收藏
页码：55 / 67
页数：13
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