Dissecting the Genetics of Osteoporosis using Systems Approaches

被引：35

作者：

Al-Barghouthi, Basel M. ^{[1
]}

Farber, Charles R. ^{[1
,2
]}

机构：

[1] Univ Virginia, Dept Biochem & Mol Genet, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Publ Hlth Sci, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

来源：

TRENDS IN GENETICS | 2019年 / 35卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; BONE-MINERAL DENSITY; COMPLEX TRAITS; THERAPEUTIC TARGETS; NETWORK ANALYSIS; GWAS; VARIANTS; DISEASE; GENES; LOCI;

D O I：

10.1016/j.tig.2018.10.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Osteoporosis is a condition characterized by low bone mineral density (BMD) and an increased risk of fracture. Traits contributing to osteoporotic fracture are highly heritable, indicating that a comprehensive understanding of bone requires a thorough understanding of the genetic basis of bone traits. Towards this goal, genome-wide association studies (GWASs) have identified over 500 loci associated with bone traits. However, few of the responsible genes have been identified, and little is known of how these genes work together to influence systems-level bone function. In this review, we describe how systems genetics approaches can be used to fill these knowledge gaps.

引用

页码：55 / 67

页数：13

共 95 条

[1] Genetic effects on gene expression across human tissues [J].

Aguet, Francois ;

Brown, Andrew A. ;

Castel, Stephane E. ;

Davis, Joe R. ;

He, Yuan ;

Jo, Brian ;

Mohammadi, Pejman ;

Park, Yoson ;

Parsana, Princy ;

Segre, Ayellet V. ;

Strober, Benjamin J. ;

Zappala, Zachary ;

Cummings, Beryl B. ;

Gelfand, Ellen T. ;

Hadley, Kane ;

Huang, Katherine H. ;

Lek, Monkol ;

Li, Xiao ;

Nedzel, Jared L. ;

Nguyen, Duyen Y. ;

Noble, Michael S. ;

Sullivan, Timothy J. ;

Tukiainen, Taru ;

MacArthur, Daniel G. ;

Getz, Gad ;

Management, Nih Program ;

Addington, Anjene ;

Guan, Ping ;

Koester, Susan ;

Little, A. Roger ;

Lockhart, Nicole C. ;

Moore, Helen M. ;

Rao, Abhi ;

Struewing, Jeffery P. ;

Volpi, Simona ;

Collection, Biospecimen ;

Brigham, Lori E. ;

Hasz, Richard ;

Hunter, Marcus ;

Johns, Christopher ;

Johnson, Mark ;

Kopen, Gene ;

Leinweber, William F. ;

Lonsdale, John T. ;

McDonald, Alisa ;

Mestichelli, Bernadette ;

Myer, Kevin ;

Roe, Bryan ;

Salvatore, Michael ;

Shad, Saboor .

NATURE, 2017, 550 (7675) :204-+

[2]

[Anonymous], 1985, BAYESIAN NETWORKS MO

[3] Network medicine: a network-based approach to human disease [J].

Barabasi, Albert-Laszlo ;

Gulbahce, Natali ;

Loscalzo, Joseph .

NATURE REVIEWS GENETICS, 2011, 12 (01) :56-68

[4] Informatics and machine learning to define the phenotype [J].

Basile, Anna Okula ;

Ritchie, Marylyn DeRiggi .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2018, 18 (03) :219-226

[5] Combined sequence-based and genetic mapping analysis of complex traits in outbred rats [J].

Baud, Amelie ;

Hermsen, Roel ;

Guryev, Victor ;

Stridh, Pernilla ;

Graham, Delyth ;

McBride, Martin W. ;

Foroud, Tatiana ;

Calderari, Sophie ;

Diez, Margarita ;

Ockinger, Johan ;

Beyeen, Amennai D. ;

Gillett, Alan ;

Abdelmagid, Nada ;

Guerreiro-Cacais, Andre Ortlieb ;

Jagodic, Maja ;

Tuncel, Jonatan ;

Norin, Ulrika ;

Beattie, Elisabeth ;

Ngan Huynh ;

Miller, William H. ;

Koller, Daniel L. ;

Alam, Imranul ;

Falak, Samreen ;

Osborne-Pellegrin, Mary ;

Martinez-Membrives, Esther ;

Canete, Toni ;

Blazquez, Gloria ;

Vicens-Costa, Elia ;

Mont-Cardona, Carme ;

Diaz-Moran, Sira ;

Tobena, Adolf ;

Hummel, Oliver ;

Zelenika, Diana ;

Saar, Kathrin ;

Patone, Giannino ;

Bauerfeind, Anja ;

Bihoreau, Marie-Therese ;

Heinig, Matthias ;

Lee, Young-Ae ;

Rintisch, Carola ;

Schulz, Herbert ;

Wheeler, David A. ;

Worley, Kim C. ;

Muzny, Donna M. ;

Gibbs, Richard A. ;

Lathrop, Mark ;

Lansu, Nico ;

Toonen, Pim ;

Ruzius, Frans Paul ;

de Bruijn, Ewart .

NATURE GENETICS, 2013, 45 (07) :767-+

[6] A high-resolution association mapping panel for the dissection of complex traits in mice [J].

Bennett, Brian J. ;

Farber, Charles R. ;

Orozco, Luz ;

Kang, Hyun Min ;

Ghazalpour, Anatole ;

Siemers, Nathan ;

Neubauer, Michael ;

Neuhaus, Isaac ;

Yordanova, Roumyana ;

Guan, Bo ;

Truong, Amy ;

Yang, Wen-pin ;

He, Aiqing ;

Kayne, Paul ;

Gargalovic, Peter ;

Kirchgessner, Todd ;

Pan, Calvin ;

Castellani, Lawrence W. ;

Kostem, Emrah ;

Furlotte, Nicholas ;

Drake, Thomas A. ;

Eskin, Eleazar ;

Lusis, Aldons J. .

GENOME RESEARCH, 2010, 20 (02) :281-290

[7] Postmenopausal Osteoporosis [J].

Black, Dennis M. ;

Rosen, Clifford J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (03) :254-262

[8] The Amazing Osteocyte [J].

Bonewald, Lynda F. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (02) :229-238

[9] An Expanded View of Complex Traits: From Polygenic to Omnigenic [J].

Boyle, Evan A. ;

Li, Yang I. ;

Pritchard, Jonathan K. .

CELL, 2017, 169 (07) :1177-1186

[10] Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025 [J].

Burge, Russel ;

Dawson-Hughes, Bess ;

Solomon, Daniel H. ;

Wong, John B. ;

King, Alison ;

Tosteson, Anna .

JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (03) :465-475

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