Genetic determinants for chemo- and radiotherapy resistance in bladder cancer

被引：42

作者：

Mari, Andrea ^{[1
]}

D'Andrea, David ^{[1
]}

Abufaraj, Mohammad ^{[1
,2
]}

Foerster, Beat ^{[1
,3
]}

Kimura, Shoji ^{[1
,4
]}

Shariat, Shahrokh F. ^{[1
,5
,6
,7
]}

机构：

[1] Med Univ Vienna, Dept Urol, Ctr Comprehens Canc, Vienna, Austria

[2] Univ Jordan, Jordan Univ Hosp, Div Urol, Dept Special Surg, Amman, Jordan

[3] Kantonsspital Winterthur, Dept Urol, Winterthur, Switzerland

[4] Jikei Univ, Sch Med, Dept Urol, Tokyo, Japan

[5] Karl Landsteiner Inst Urol & Androl, Vienna, Austria

[6] Univ Texas Southwestern Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA

[7] Weill Cornell Med Coll, Dept Urol, New York, NY USA

来源：

TRANSLATIONAL ANDROLOGY AND UROLOGY | 2017年 / 6卷 / 06期

关键词：

Bladder cancer (BCa); urothelial carcinoma; chemoresistance; radioresistance; cisplatin resistance; APOPTOSIS-INDUCING LIGAND; SINGLE NUCLEOTIDE POLYMORPHISMS; CELL LUNG-CANCER; DNA-REPAIR; STEM-CELLS; NEOADJUVANT CHEMOTHERAPY; CISPLATIN-RESISTANCE; MOLECULAR-MECHANISMS; INCREASED EXPRESSION; PLATINUM RESISTANCE;

D O I：

10.21037/tau.2017.08.19

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Bladder cancer (BCa) is burdened by high rates of chemo- and radio-resistance. We reviewed and summarized the current evidence regarding the genetic determinants of resistance in patients treated with chemotherapy and/or radiotherapy (RT) for BCa. Genetic heterogeneity may preexist to treatment arising with tumorigenesis or increasing progressively during the treatment. Several biological pathways seem to be involved in the cellular response to treatment. These pathways comprehend mechanisms leading to modify the intracellular concentration of the drug, mechanisms leading to increase the repair of DNA damage caused by the treatment, mechanisms leading to increase cell survival, despite DNA damage, acting on the signaling pathways affecting apoptosis, mechanisms promoting autophagy. In the present review, we focused on the genetic determinants of resistance affecting the aforementioned mechanisms.

引用

页码：1081 / 1089

页数：9

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