Inorganic nanoparticle-based advanced cancer therapies: Promising combination strategies

被引:39
作者
Amaldoss, Maria John Newton [1 ,2 ]
Yang, Jia-Lin [1 ]
Koshy, Pramod [2 ]
Unnikrishnan, Ashwin [1 ]
Sorrell, Charles C. [2 ]
机构
[1] UNSW Sydney, Prince Wales Clin Sch, Lowy Canc Res Ctr, Adult Canc Program, Sydney, NSW 2052, Australia
[2] UNSW Sydney, Sch Mat Sci & Engn, Sydney, NSW 2052, Australia
关键词
Nanoparticle drug delivery; Cancer drug delivery; Cancer therapy; Combination therapy; RNAi; siRNA drug delivery; Nanocarriers; MESOPOROUS SILICA NANOPARTICLES; IRON-OXIDE NANOPARTICLES; STEM-CELLS; GOLD NANOPARTICLES; SIRNA DELIVERY; SIGNALING PATHWAYS; RNA-INTERFERENCE; MULTIDRUG-RESISTANCE; TARGETING NOTCH; CELLULAR UPTAKE;
D O I
10.1016/j.drudis.2022.103386
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Inorganic nanoparticles for drug delivery in cancer treatment offer many potential advantages because they can maximize therapeutic effect through targeting ligands while minimizing off-target side-effects through drug adsorption and infiltration. Although inorganic nanoparticles were introduced as drug carriers, they have emerged as having the capacity for combined therapeutic capabilities, including anticancer effects through cytotoxicity, suppression of oncogenes and cancer cell signaling pathway inhibition. The most promising advanced strategies for cancer therapy are as synergistic platforms for RNA interference (siRNA, miRNA, shRNA) and as synergistic drug delivery agents for the inhibition of cancer cell signaling pathways. The present work summarizes relevant current work, the promise of which is suggested by a projected compound annual growth rate of similar to 20% for drug delivery alone.
引用
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页数:14
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