Evolution of synovitis in osteoarthritic knees and its association with clinical features

被引：39

作者：

de lange-Brokaar, J. E. ^{[1
]}

Ioan-Facsinay, A. ^{[1
]}

Yusuf, E. ^{[1
]}

Kroon, H. M. ^{[2
]}

Zuurmond, A. -M. ^{[3
]}

Stojanovic-Susulic, V.

Nelissen, R. G. H. H. ^{[4
]}

Bloem, J. L. ^{[2
]}

Kloppenburg, M. ^{[1
,5
]}

机构：

[1] Leiden Univ, Dept Rheumatol, Med Ctr, C1-45,Postbus 9600, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands

[3] TNO, Leiden, Netherlands

[4] Leiden Univ, Dept Orthopaed, Med Ctr, Leiden, Netherlands

[5] Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands

来源：

OSTEOARTHRITIS AND CARTILAGE | 2016年 / 24卷 / 11期

关键词：

Osteoarthritis; Synovitis; MRI; Cartilage; BML; Progression; CONTRAST-ENHANCED MRI; CARTILAGE LOSS; MICROSCOPIC FEATURES; OUTCOME MEASURE; SCORING SYSTEM; JOINT EFFUSION; FOLLOW-UP; PAIN; OA; INFLAMMATION;

D O I：

10.1016/j.joca.2016.05.021

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: To investigate the course of synovitis on contrast-enhanced magnetic resonance images ( CE-MRI) in osteoarthritic knees over 2 years, and its association with pain and cartilage deterioration. Design: Consecutive patients ( n = 39, mean age 61 years, 79% woman, median ( range) body mass index ( BMI) 29 ( 24-48) kg/mm(2)) with clinical osteoarthritis ( OA) were included. Baseline and follow-up CE-MRI ( 3 T) were scored paired in chronological order for synovitis ( semi-quantitatively at 11 sites ( range 0-22)), cartilage deterioration and bone marrow lesions ( BMLs) ( semi-quantitatively according to Knee Osteoarthritis Scoring System ( KOSS)). Changes in sum scores were calculated. Cartilage deterioration was defined as change of >= 2 above the smallest detectable change ( SDC). Pain was assessed by standardized questionnaires. Analysis of covariance ( ANCOVA) and linear regression models were used to investigate association between synovitis change and cartilage deterioration and between synovitis change or cartilage deterioration and change in pain. Results: The total synovitis score did not change over 2 years ( mean change 0.2 ( standard deviation ( SD) 3.2)), although changes in individual patients were observed. Cartilage deterioration was observed in 51% of patients. Synovitis change score was lower in patients without compared to patients with cartilage deterioration, taking BML change in account ( mean difference -2.1 ( -4.1 to -0.1)). Change in synovitis was not associated with change in pain, whereas cartilage deterioration was associated with change in Intermittent and Constant OsteoArthritis Pain ( ICOAP) constant pain in adjusted models ( unstandardised coefficient ( B) ( 95% confidence interval ( CI)) 2.8 ( 0.4-5.3)). Conclusions: In individual patients synovitis fluctuates during disease course. Synovitis change was not associated with change in pain. Increase in synovitis is associated with cartilage deterioration, suggesting a role for synovitis as a target for disease-modifying treatment. (C) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：1867 / 1874

页数：8

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