Malabaricone C from Myristica cinnamomea Exhibits Anti-Quorum Sensing Activity

被引：115

作者：

Chong, Yee Meng ^{[1
]}

Yin, Wai Fong ^{[1
]}

Ho, Chia Yong ^{[1
]}

Mustafa, Mohamad Rais ^{[2
]}

Hadi, A. Hamid A. ^{[2
]}

Awang, Khalijah ^{[2
]}

Narrima, Putri ^{[2
]}

Koh, Chong-Lek ^{[3
]}

Appleton, David R. ^{[2
,4
]}

Chan, Kok-Gan ^{[1
]}

机构：

[1] Univ Malaya, Inst Biol Sci, Div Genet & Mol Biol, Fac Sci, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Dept Pharmacol, Fac Med, Ctr Nat Prod Res & Drug Dev, Kuala Lumpur 50603, Malaysia

[3] Nanyang Technol Univ, Natl Inst Educ, Nat Sci & Sci Educ AG, Singapore 637616, Singapore

[4] Univ Putra Malaysia, UPM MTDC Technol Ctr 3, Sime Darby Technol Ctr Sdn Bhd, Serdang 43400, Selangor, Malaysia

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 10期

关键词：

GENE-EXPRESSION; SIGNAL; INHIBITION; BACTERIA; PLANTS;

D O I：

10.1021/np100872k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.

引用

页码：2261 / 2264

页数：4

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