The cation channel TRPM8 influences the differentiation and function of human monocytes

被引：8

作者：

Hornsby, Eve ^{[1
,2
]}

King, Hamish W. ^{[1
,2
]}

Peiris, Madusha ^{[3
]}

Buccafusca, Roberto ^{[4
]}

Lee, Wing-Yiu Jason ^{[1
,2
]}

Wing, Elinor S. ^{[1
,2
]}

Blackshaw, L. Ashley ^{[3
]}

Lindsay, James O. ^{[1
,2
,5
]}

Stagg, Andrew J. ^{[1
,2
]}

机构：

[1] Queen Mary Univ London, Ctr Immunobiol, London E1 2AT, England

[2] Queen Mary Univ London, Barts & London Sch Med & Dent, London E1 2AT, England

[3] Queen Mary Univ London, Ctr Neurosci & Trauma, Blizard Inst, Barts & London Sch Med & Dent, London, England

[4] Queen Mary Univ London, Sch Biol & Chem Sci, Mile End Rd, London, England

[5] Barts Hlth NHS Trust, Royal London Hosp, Dept Gastroenterol, London, England

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2022年 / 112卷 / 03期

关键词：

LPS; monocyte-derived macrophage; phagocytosis; TRP channels; DENDRITIC CELLS; STEADY-STATE; CARDIAC MACROPHAGES; PROSTATE-CANCER; ION-CHANNEL; ACTIVATION; IDENTIFICATION; PROLIFERATION; PROTECTION; INFECTION;

D O I：

10.1002/JLB.1HI0421-181R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Monocytes are mononuclear phagocytes that can differentiate to a variety of cell fates under the influence of their microenvironment and hardwired commitment. We found that inhibition of TRPM8 in human blood CD14(+) monocytes during a critical 3-h window at the beginning of their differentiation into macrophages led to enhanced survival and LPS-driven TNF alpha production after 24 h. TRPM8 antagonism also promoted LPS-driven TNF alpha production in CD14(+) monocytes derived from the intestinal mucosa. Macrophages that had been derived for 6 days under blockade of TRPM8 had impaired phagocytic capacity and were transcriptionally distinct. Most of the affected genes were altered in a way that opposed normal monocyte to macrophage differentiation indicating that TRPM8 activity promotes aspects of this differentiation programme. Thus, we reveal a novel role for TRPM8 in regulating human CD14(+) monocyte fate and function.

引用

页码：365 / 381

页数：17

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