Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?

被引：32

作者：

Kittel-Schneider, Sarah ^{[1
,29
]}

Arteaga-Henriquez, Gara ^{[2
,3
,4
,5
]}

Vasquez, Alejandro Arias ^{[6
,7
]}

Asherson, Phil ^{[8
]}

Banaschewski, Tobias ^{[9
]}

Brikell, Isabell ^{[10
,11
,12
,27
]}

Buitelaar, Jan ^{[13
,14
]}

Cormand, Bru ^{[15
,16
,17
,18
]}

Faraone, Stephen, V ^{[19
,20
]}

Freitag, Christine M. ^{[21
]}

Ginsberg, Ylva ^{[22
,23
]}

Haavik, Jan ^{[24
,25
]}

Hartman, Catharina A. ^{[26
]}

Kuntsi, Jonna ^{[8
]}

Larsson, Henrik ^{[27
,28
]}

Matura, Silke ^{[29
]}

McNeill, Rhiannon, V ^{[1
]}

Ramos-Quiroga, J. Antoni ^{[2
,3
,4
,5
]}

Ribases, Marta ^{[2
,3
,4
,15
]}

Romanos, Marcel ^{[30
]}

Vainieri, Isabella ^{[8
]}

Franke, Barbara ^{[6
,7
]}

Reif, Andreas ^{[29
]}

机构：

[1] Univ Hosp Wurzburg, Ctr Mental Hlth, Dept Psychiat Psychosomat Med & Psychotherapy, Margarete Hoppel Pl 1, D-97080 Wurzburg, Germany

[2] Hosp Univ Vall dHebron, Dept Psychiat, Barcelona, Catalonia, Spain

[3] Univ Autonoma Barcelona, Vall dHebron Res Inst VHIR, Psychiat Genet Unit, Grp Psychiat Mental Hlth & Addict, Barcelona, Catalonia, Spain

[4] Biomed Network Res Ctr Mental Hlth CIBERSAM, Madrid, Spain

[5] Univ Autonoma Barcelona, Dept Psychiat & Forens Med, Barcelona, Catalonia, Spain

[6] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands

[7] Radboud Univ Nijmegen, Dept Psychiat, Med Ctr, Nijmegen, Netherlands

[8] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, De Crespigny Pk, London SE5 8AF, England

[9] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Mannheim, Germany

[10] Aarhus Univ, Natl Ctr Register Based Res, Dept Econ & Business Econ Aarhus BSS, Fuglesangs Alle 26, DK-8210 Aarhus V, Denmark

[11] iPSYCH Lundbeck Fdn Initiat Integrat Psychiat Res, Copenhagen, Denmark

[12] iPSYCH Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark

[13] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Med Ctr, Nijmegen, Netherlands

[14] Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands

[15] Univ Barcelona, Fac Biol, Dept Genet, Catalonia, Spain

[16] Inst Biomed Univ Barcelona IBUB, Catalonia, Spain

[17] Ctr Invest Biomed Red Enfermedades Raras CIBERER, Barcelona, Spain

[18] Inst Recerca St Joan de Deu IR SJD, Esplugas de Llobregat, Catalonia, Spain

[19] SUNY Upstate Med Univ, Dept Psychiat & Neurosci, Syracuse, NY 13210 USA

[20] SUNY Upstate Med Univ, Dept Physiol, Syracuse, NY 13210 USA

[21] Goethe Univ, Univ Hosp Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, Deutschordenstr 50, D-60528 Frankfurt, Germany

[22] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Norra Stationsgatan 69, SE-11364 Stockholm, Sweden

[23] Stockholm Hlth Care Serv, Norra Stationsgatan 69, SE-11364 Stockholm, Sweden

[24] Haukeland Hosp, Bergen Ctr Brain Plast, Div Psychiat, Postboks 1400, N-5021 Bergen, Norway

[25] Univ Bergen, Dept Biomed, Bergen, Norway

[26] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Dept Psychiat, POB 30-001, NL-9700 RB Groningen, Netherlands

[27] Karolinska Inst, Dept Med Epidemiol & Biostat, Box 281, S-17177 Stockholm, Sweden

[28] Orebro Univ, Sch Med Sci, Campus USO, S-70182 Orebro, Sweden

[29] Goethe Univ, Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Heinrich Hoffmann Str 10, D-60528 Frankfurt, Germany

[30] Univ Hosp Wurzburg, Ctr Mental Hlth, Dept Child & Adolescent Psychiat Psychotherapy &, Margarete Hoppel Pl 1, D-97080 Wurzburg, Germany

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2022年 / 132卷

关键词：

Attention-deficit; hyperactivity disorder; Somatic disorders; Non-mental disease; Asthma; Obesity; Migraine; Diabetes mellitus type II; Elimination disorders; Epilepsy; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT-HYPERACTIVITY DISORDER; RESTLESS LEGS SYNDROME; CONGENITAL HEART-DISEASE; GENOME-WIDE ASSOCIATION; AUTISM SPECTRUM DISORDER; MENTAL-HEALTH PROBLEMS; QUALITY-OF-LIFE; PSYCHIATRIC-DISORDERS; OXIDATIVE STRESS;

D O I：

10.1016/j.neubiorev.2021.10.035

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Several non-mental diseases seem to be associated with an increased risk of ADHD and ADHD seems to be associated with increased risk for non-mental diseases. The underlying trajectories leading to such brain-body co occurrences are often unclear are there direct causal relationships from one disorder to the other, or does the sharing of genetic and/or environmental risk factors lead to their occurring together more frequently or both? Our goal with this narrative review was to provide a conceptual synthesis of the associations between ADHD and non-mental disease across the lifespan. We discuss potential shared pathologic mechanisms, genetic background and treatments in co-occurring diseases. For those co-occurrences for which published studies with sufficient sample sizes exist, meta-analyses have been published by others and we discuss those in detail. We conclude that non-mental diseases are common in ADHD and vice versa and add to the disease burden of the patient across the lifespan. Insufficient attention to such co-occurring conditions may result in missed diagnoses and suboptimal treatment in the affected individuals.

引用

页码：1157 / 1180

页数：24

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