In vivo and in vitro antitumor activity of doxorubicin-loaded magnetic fluids

被引：7
作者：
Park, S. I. [1 ]
Lim, J. H. [2 ]
Hwang, Y. H. [2 ]
Kim, K. H. [3 ]
Kim, S. M. [3 ]
Kim, J. H. [4 ]
Kim, C. G. [1 ,4 ]
Kim, C. O. [1 ,4 ]
机构：
[1] Chungnam Natl Univ, Dept Mat Sci & Engn, Taejon 305764, South Korea
[2] Chungnam Natl Univ, Div Vet Pharmacol & Toxicol, Taejon 305764, South Korea
[3] Chungnam Natl Univ Hosp, Dept Nucl Med, Taejon 305764, South Korea
[4] Chungnam Natl Univ, Res Ctr Adv Magnet Mat, Taejon 305764, South Korea
来源：
PHYSICA STATUS SOLIDI C - CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 4, NO 12 | 2007年 / 4卷 / 12期
关键词：
D O I：
10.1002/pssc.200777126
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Doxorubicin-loaded magnetic particles with lecithin and polyethylene glycol as an interlayer were synthesized by multi-step process of high temperature thermal decomposition and ultrasonic, respectively. The change of particle size and the magnetic property were investigated for the estimation of the carrier characteristic with doxorubicin addition. And, the loading efficiency of drug and the loaded drug released fraction were discussed for the estimation of drug effect. Also, the remedial efficiency of adsorbed drug on the magnetic nanoparticle was investigated by comparing the cytotoxicity of tumor cell between bare-and doxorubicin-loaded magnetic nanoparticles. And, in-vivo test was performed to estimate the effect of anticancer therapy by using C57BL/6 mice as an animal sample. (C) 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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页码：4345 / +
页数：2
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