Lipotoxicity: a driver of heart failure with preserved ejection fraction?

被引：29
作者：
Leggat, Jennifer [1 ]
Bidault, Guillaume [1 ]
Vidal-Puig, Antonio [1 ]
机构：
[1] Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England
来源：
CLINICAL SCIENCE | 2021年 / 135卷 / 19期
基金：
英国医学研究理事会;
关键词：
FATTY-ACID OXIDATION; CORONARY MICROVASCULAR DYSFUNCTION; MYOCARDIAL SUBSTRATE METABOLISM; POSITRON-EMISSION-TOMOGRAPHY; ACTIVATED RECEPTOR-ALPHA; PROTEIN-KINASE-C; DIASTOLIC DYSFUNCTION; CARDIAC-HYPERTROPHY; NITRIC-OXIDE; INSULIN-RESISTANCE;
D O I：
10.1042/CS20210127
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Heart failure with preserved ejection fraction (HFpEF) is a growing public health concern, with rising incidence alongside high morbidity and mortality. However, the pathophysiology of HFpEF is not yet fully understood. The association between HFpEF and themetabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid accumulation and subsequent lipotoxicity.
引用
收藏
页码：2265 / 2283
页数：19
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