The endophytic Aspergillus strains: A bountiful source of natural products

被引：45
作者：
Hagag, Ahmed [1 ]
Abdelwahab, Miada F. [2 ]
Abd El-kader, Adel M. [1 ,3 ]
Fouad, Mostafa A. [2 ]
机构：
[1] Deraya Univ, Dept Pharmacognosy, Fac Pharm, New Minia City, Egypt
[2] Minia Univ, Dept Pharmacognosy, Fac Pharm, Al Minya 61519, Egypt
[3] Al Azhar Univ, Dept Pharmacognosy, Fac Pharm, Assiut, Egypt
来源：
JOURNAL OF APPLIED MICROBIOLOGY | 2022年 / 132卷 / 06期
关键词：
Aspergillus; biological activity; endophytic fungi; secondary metabolites; FUNGAL ENDOPHYTES; SECONDARY METABOLITES; DIVERSITY; SP;
D O I：
10.1111/jam.15489
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Fungi that invade plant inner tissues without inducing disease symptoms are known as fungal endophytes. They represent a promising and tremendous reservoir of natural products with valuable biological potentials for application in medicine, agriculture and industry. Among the numerous existing endophytic fungi, Aspergillus strains constitute one of the most prolific sources of secondary metabolites with diverse chemical classes and interesting biological activities. This review covers the literature of the year 2020, reporting the isolation of 202 compounds obtained from more than 10 different endophytic Aspergillus species associated with different host plants. Analysis and interpretation of the collected data revealed that chemical investigation of endophytes belonging to the genus Aspergillus may greatly contribute to the discovery of potential drug leads. The isolated metabolites were chemically various and exhibited diverse biological activities such as antibacterial, anti-cancer, anti-plasmodial, anti-inflammatory, antioxidant, immunosuppressive and antifungal activities. Moreover, adoption of advanced technology in molecular biology together with modern chemical tools is anticipated to improve the discovery of new biopharmaceuticals from this valuable microbial world in the future.
引用
收藏
页码：4150 / 4169
页数：20
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