Biomarkers in the exhaled breath condensate of healthy adults: Mapping the path towards reference values

被引:1
作者
Koutsokera, Angela [2 ]
Loukides, Stelios [1 ]
Gourgoulianis, Konstantinos I. [2 ]
Kostikas, Konstantinos [2 ]
机构
[1] Univ Athens, Sch Med, Resp Med Dept 2, Athens 16673, Greece
[2] Univ Athens, Sch Med, Dept Resp Med, Athens 16673, Greece
关键词
exhaled breath condensate; normal values; healthy subjects; biomarkers; pH; hydrogen peroxide; 8-isoprostane;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The need for non-invasive assessment of airway inflammation is imperative, since inflammatory airway diseases, such as asthma and COPD, are characterized by variation in their clinical presentation throughout their course. Exhaled breath condensate (EBC) collection represents a rather appealing method that can be used to conveniently and noninvasively collect a wide range of volatile and non-volatile molecules from the respiratory tract, without affecting airway function or inflammation. Although promising, EBC is currently used only as a research tool, due to the lack of appropriate standardization and the absence of reference values. The large number of measurable biomarkers and the diversity of the used methodologies are some of the points that hamper its wide clinical application. This review focuses mainly on the presentation of normal values of the most widely studied EBC markers as reported by investigators that have used healthy subjects as controls or as a basic study population. These biomarkers include hydrogen peroxide, NO-related products, arachidonic acid metabolites and pH. From those biomarkers, the only one with established reference values in healthy subjects is EBC pH, whereas the majority of the rest need further refinement and standardization of the methodologies used. Different subpopulations and the effect of various factors on healthy subjects are also reported, in an effort to delineate future directions that may lead to the establishment of reference values.
引用
收藏
页码:620 / 630
页数:11
相关论文
共 50 条
[41]   NOx in exhaled breath condensate is related to allergic sensitization in young and middle-aged adults [J].
Aldakheel, Fahad M. ;
Bourke, Jane E. ;
Thomas, Paul S. ;
Matheson, Melanie C. ;
Abramson, Michael J. ;
Hamilton, Garun S. ;
Lodge, Caroline J. ;
Thompson, BruceR. ;
Walters, E. Haydn ;
Allen, Katrina J. ;
Erbas, Bircan ;
Perret, Jennifer L. ;
Dharmage, Shyamali C. ;
Lowe, Adrian J. .
CLINICAL AND EXPERIMENTAL ALLERGY, 2019, 49 (02) :171-179
[42]   The effect of inhaled chromium on different exhaled breath condensate biomarkers among chrome-plating workers [J].
Caglieri, A ;
Goldoni, M ;
Acampa, O ;
Andreoli, R ;
Vettori, MV ;
Corradi, M ;
Apostoli, P ;
Mutti, A .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2006, 114 (04) :542-546
[43]   Metabonomic analysis of exhaled breath condensate in adults by nuclear magnetic resonance spectroscopy [J].
de Laurentiis, G. ;
Paris, D. ;
Melck, D. ;
Maniscalco, M. ;
Marsico, S. ;
Corso, G. ;
Motta, A. ;
Sofia, M. .
EUROPEAN RESPIRATORY JOURNAL, 2008, 32 (05) :1175-1183
[44]   Assessment of the impact of collection temperature and sampler design on the measurement of exhaled breath condensate pH in healthy horses [J].
Whittaker, Andrew G. ;
Love, Sandy ;
Parkin, Timothy D. H. ;
Duz, Marco ;
Cathcart, Michael ;
Hughes, Kristopher J. .
VETERINARY JOURNAL, 2012, 191 (02) :208-212
[45]   Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners [J].
Casimirri, Enrico ;
Stendardo, Mariarita ;
Bonci, Melissa ;
Andreoli, Roberta ;
Bottazzi, Barbara ;
Leone, Roberto ;
Schito, Michela ;
Vaccari, Alice ;
Papi, Alberto ;
Contoli, Marco ;
Corradi, Massimo ;
Boschetto, Piera .
BIOMARKERS, 2016, 21 (02) :115-122
[46]   Potential asthma biomarkers identified by nontargeted proteomics of extracellular vesicles in exhaled breath condensate [J].
Hara, Reina ;
Takeda, Yoshito ;
Enomoto, Takatoshi ;
Yoshimura, Hanako ;
Yamamoto, Makoto ;
Tanizaki, Satoshi ;
Shirai, Yuya ;
Kawasaki, Takahiro ;
Nakayama, Mana ;
Amiya, Saori ;
Adachi, Yuichi ;
Noda, Yoshimi ;
Niitsu, Takayuki ;
Edahiro, Ryuya ;
Yaga, Moto ;
Hosono, Yuki ;
Naito, Maiko ;
Masuhiro, Kentaro ;
Naito, Yujiro ;
Shiroyama, Takayuki ;
Miyake, Kotaro ;
Fukushima, Kiyoharu ;
Koyama, Shohei ;
Iwahori, Kota ;
Hirata, Haruhiko ;
Nagatomo, Izumi ;
Kawashima, Yusuke ;
Nogami-Itoh, Mari ;
Kumanogoh, Atsushi .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: GLOBAL, 2025, 4 (02)
[47]   Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease [J].
Freund, Romain ;
Sauvain, Jean-Jacques ;
Suarez, Guillaume ;
Wild, Pascal ;
Charreau, Thomas ;
Debatisse, Amelie ;
Sakthithasan, Kirushanthi ;
Jouannique, Valerie ;
Pralong, Jacques A. ;
Canu, Irina Guseva .
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY, 2024, 19 (01)
[48]   Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease [J].
Romain Freund ;
Jean‑Jacques Sauvain ;
Guillaume Suarez ;
Pascal Wild ;
Thomas Charreau ;
Amélie Debatisse ;
Kirushanthi Sakthithasan ;
Valérie Jouannique ;
Jacques A. Pralong ;
Irina Guseva Canu .
Journal of Occupational Medicine and Toxicology, 19
[49]   Biomarkers of nitrosative stress in exhaled breath condensate and serum among patients with cystic fibrosis [J].
Galiniak, Sabina ;
Rohovyk, Nataliya ;
Rachel, Marta .
ADVANCES IN MEDICAL SCIENCES, 2023, 68 (02) :202-207
[50]   Acute effects of smoking and food consumption on breath condensate pH in healthy adults [J].
Calusic, Anita Ljubicic ;
Varnai, Veda M. ;
Macan, Jelena .
EXPERIMENTAL LUNG RESEARCH, 2011, 37 (02) :92-100