Polysaccharide storage myopathy in Cob Normand draft horses

被引：9

作者：

Larcher, T. ^{[1
]}

Herszberg, B. ^{[2
]}

Molon-Noblot, S. ^{[3
]}

Guigand, L. ^{[1
]}

Chaffaux, S. ^{[2
]}

Guerin, G. ^{[2
]}

Cherel, Y. ^{[1
]}

机构：

[1] INRA, Ecole Natl Vet, UMR 703, F-44307 Nantes, France

[2] INRA, Lab Genet Biochem & Cyotogenet, F-78350 Jouy En Josas, France

[3] Ctr Rech Mirabel, MSD Chibret, F-63963 Clermont Ferrand, France

来源：

VETERINARY PATHOLOGY | 2008年 / 45卷 / 02期

关键词：

histopathology; horses; myopathy; polysaccharide storage;

D O I：

10.1354/vp.45-2-154

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gluteus medius muscle was sampled from 53 Cob Normand horses for histologic evaluation. Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type 11 fibers was increased (67.7 +/- 21.4 mu m) compared with normal ones (57.3 +/- 19.7 mu m). Two groups were distinguished by quantitative study. The first group (n = 14; 26%) was characterized by a low percentage of fibers (m = 0.98%) containing aggregates occurring singly or in perifascicular clusters without myopathic changes. The second group (n = 6; 11%) was characterized by a high percentage (in = 18.1%) of fibers containing aggregates scattered in biopsy with chronic myopathic changes. Rebiopsy of 4 horses showed an increase with time in the number of aggregate-containing fibers for horses of the first group only. In I necropsied horse, aggregates were observed in a wide range of muscles including smooth muscles. Ultrastructurally, granular material was found interspersed among arrays of filamentous material.

引用

页码：154 / 158

页数：5

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