Efficacy of high dose steroid therapy in children with severe acute transverse myelitis

被引：56
作者：
Defresne, P
Meyer, L
Tardieu, M
Scalais, E
Nuttin, C
De Bont, B
Loftus, G
Landrieu, P
Kadhim, H
Sébire, G
机构：
[1] Univ Catholique Louvain, Neurol Serv, Dept Pediat, Clin Univ St Luc, B-1200 Brussels, Belgium
[2] ULB, CHU, Brugmann HUDERF, Unite Neuropathol,Serv Anatomopathol, Brussels, Belgium
[3] Univ Paris 11, Hop Bicetre, Dept Pediat, Neurol Serv, Le Kremlin Bicetre, France
[4] Univ Paris 11, Hop Bicetre, INSERM U292, Serv Epidemiol, Le Kremlin Bicetre, France
[5] Clin Esperance, Serv Pediat, Montegnee, Belgium
[6] Ctr Hosp Luxembourg, Serv Pediat, Luxembourg, Luxembourg
[7] Clin Jolimont, Serv Pediat, La Louviere, Belgium
[8] Univ Coll Hosp Galway, Dept Pediat, Galway, Ireland
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2001年 / 71卷 / 02期
关键词：
steroids; acute transverse myelopathy; encephalomyelitis;
D O I：
10.1136/jnnp.71.2.272
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
No effective treatment has been demonstrated for patients with acute transverse myelopathy. In a multicentre controlled study, 12 children with severe acute transverse myelopathy were treated with intravenous methylprednisolone (IVMP) and compared with a historical group of 17 patients. The treatment had a significant effect on the proportion of patients walking independently at I month and on the proportion with full recovery at I year, with no differences in the frequency of complications between the two groups.
引用
收藏
页码：272 / 274
页数：3
相关论文
共 21 条
  • [1] AUTOIMMUNE FEATURES OF ACUTE TRANSVERSE MYELOPATHY
    ABRAMSKY, O
    TEITELBAUM, D
    [J]. ANNALS OF NEUROLOGY, 1977, 2 (01) : 36 - 40
  • [2] Acute transverse myelitis - A localized form of postinfectious encephalomyelitis
    AlDeeb, SM
    Yaqub, BA
    Bruyn, GW
    Biary, NM
    [J]. BRAIN, 1997, 120 : 1115 - 1122
  • [3] A RANDOMIZED, CONTROLLED TRIAL OF CORTICOSTEROIDS IN THE TREATMENT OF ACUTE OPTIC NEURITIS
    BECK, RW
    CLEARY, PA
    ANDERSON, MM
    KELTNER, JL
    SHULTS, WT
    KAUFMAN, DI
    BUCKLEY, EG
    CORBETT, JJ
    KUPERSMITH, MJ
    MILLER, NR
    SAVINO, PJ
    GUY, JR
    TROBE, JD
    MCCRARY, JA
    SMITH, CH
    CHROUSOS, GA
    THOMPSON, HS
    KATZ, BJ
    BRODSKY, MC
    GOODWIN, JA
    ATWELL, CW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (09) : 581 - 588
  • [4] BERMAN M, 1981, Neurology, V31, P966
  • [5] Spinal cord infarction: Etiology and outcome
    Cheshire, WP
    Santos, CC
    Massey, W
    Howard, JF
    [J]. NEUROLOGY, 1996, 47 (02) : 321 - 330
  • [6] DUNNE K, 1986, DEV MED CHILD NEUROL, V28, P198
  • [7] MULTIPLE-SCLEROSIS IN CHILDHOOD - CLINICAL PROFILE IN 125 PATIENTS
    DUQUETTE, P
    MURRAY, TJ
    PLEINES, J
    EBERS, GC
    SADOVNICK, D
    WELDON, P
    WARREN, S
    PATY, DW
    UPTON, A
    HADER, W
    NELSON, R
    AUTY, A
    NEUFELD, B
    MELTZER, C
    [J]. JOURNAL OF PEDIATRICS, 1987, 111 (03) : 359 - 363
  • [8] Multiple sclerosis in childhood: Clinical features of 149 cases
    Ghezzi, A
    Deplano, V
    Faroni, J
    Grasso, MG
    Liguori, M
    Marrosu, G
    Pozzilli, C
    Simone, IL
    Zaffaroni, M
    [J]. MULTIPLE SCLEROSIS, 1997, 3 (01): : 43 - 46
  • [9] THE USE OF IMMUNOSUPPRESSIVE AGENTS IN THE TREATMENT OF MULTIPLE-SCLEROSIS - A CRITICAL-REVIEW
    GOODIN, DS
    [J]. NEUROLOGY, 1991, 41 (07) : 980 - 985
  • [10] TRANSVERSE MYELITIS - RETROSPECTIVE ANALYSIS OF 33 CASES, WITH DIFFERENTIATION OF CASES ASSOCIATED WITH MULTIPLE-SCLEROSIS AND PARAINFECTIOUS EVENTS
    JEFFERY, DR
    MANDLER, RN
    DAVIS, LE
    [J]. ARCHIVES OF NEUROLOGY, 1993, 50 (05) : 532 - 535
123