High-affinity T cell receptors for adoptive cell transfer

被引：3
作者：
Isser, Ariel [1 ]
Schneck, Jonathan P. [2 ,3 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Pathol Med & Oncol, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Immunol Program, Inst Cellular Engn, Baltimore, MD 21205 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 01期
基金：
美国国家科学基金会;
关键词：
CANCER REGRESSION; GENE-THERAPY; ANTIGEN; CD4(+); MELANOMA; IMMUNITY; MICE;
D O I：
10.1172/JCI125471
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Adoptive cell transfer (ACT) of engineered T cell receptors (TCRs) for cancer immunotherapy has evolved from simple gene transfer of isolated TCRs to various affinity enhancement techniques that overcome limitations imposed by central and peripheral tolerance on TCR affinity. In the current issue of the JCI, Poncette et al. used mice with human TCR alpha beta and HLA gene loci to discover CD4(+) TCRs of optimal affinity for cancer testis antigen (CTA) NY-ESO-1. They combined this TCR with a previously discovered NY-ESO-1-specific CD8(+) TCR in an ACT fibrosarcoma tumor model to demonstrate the importance of T cell help in mediating antitumor responses.
引用
收藏
页码：69 / 71
页数：3
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