Ca2+-activated Cl- channels:: A newly emerging anion transport family.

被引：0
|
作者：
Fuller, CM [1 ]
Ji, HL [1 ]
Elble, R [1 ]
Pauli, BU [1 ]
Benos, DJ [1 ]
机构：
[1] Univ Alabama, Dept Physiol & Biophys, Birmingham, AL 35294 USA
来源：
CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS | 2000年 / 1208卷
关键词：
epithelia; patch-clamp; cloning; expression; HEK-293; cells;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new family of chloride transport proteins with extensive homology to a Ca2+-sensitive Cl- channel (CaCC) originally cloned from bovine trachea has been identified. The new members of this family have been identified in human, murine, and bovine epithelia, in addition to some other tissues, such as brain and endothelia. Heterologous expression of these proteins in Xenopus oocytes or HEK 293 cells is associated with the appearance of a novel Ca2+-sensitive chloride conductance pathway. The expressed current is sensitive to inhibitors such as DIDS and niflumic acid. In addition, at least one family member acts as an endothelial cell adhesion molecule.
引用
收藏
页码：269 / 270
页数：2
相关论文
共 50 条
  • [21] Differences in regulation of Ca2+-activated Cl- channels in colonic and parotid secretory cells
    Arreola, J
    Melvin, JE
    Begenisich, T
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1998, 274 (01): : C161 - C166
  • [22] Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels
    Terashima, Hiroyuki
    Picollo, Alessandra
    Accardi, Alessio
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (48) : 19354 - 19359
  • [23] Ca2+-activated Cl- channels as Ca2+ sensors with particular reference to the modulation of neuronal excitability
    Kenyon, JL
    Scott, RH
    CALCIUM-ACTIVATED CHLORIDE CHANNELS, 2002, 53 : 135 - 166
  • [24] Ca2+-activated Cl- channels of the ClCa family are present in rat olfactory cilia and may participate in odor transduction
    Gonzalez, Carolina
    Vera, Jorge
    Riveros, Alejandra
    Gonzalez-Billaud, Christian
    Bono, Maria Rosa
    Bacigalupo, Juan
    CHEMICAL SENSES, 2011, 36 (01) : E61 - E62
  • [25] Ca2+-activated Cl- currents in pulmonary arterial myocytes
    Clapp, LH
    Turner, JL
    Kozlowski, RZ
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 270 (05): : H1577 - H1584
  • [26] Ca2+-activated Cl- conductances in cultured airway epithelia
    Zhang, H
    Parker, S
    Barrett, KE
    Benos, DJ
    Fuller, CM
    FASEB JOURNAL, 2001, 15 (05): : A847 - A847
  • [27] CFTR AND CA2+-ACTIVATED CL- CHANNELS IN A PRIMARY HUMAN AIRWAY GLAND CELL MODEL
    Fischer, H.
    Zlock, L.
    Illek, B.
    Sachs, L.
    Finkbeiner, W. E.
    Widdicombe, J. H.
    PEDIATRIC PULMONOLOGY, 2009, : 233 - 234
  • [28] Peripheral antinociception induced by δ-opioid receptors activation, but not μ- or κ-, is mediated by Ca2+-activated Cl- channels
    Pacheco, Daniela da Fonseca
    da Fonseca Pacheco, Cinthia Mara
    Gama Duarte, Igor Dimitri
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 674 (2-3) : 255 - 259
  • [29] Adult alveolar type II cells lack cAMP and Ca2+-activated Cl- channels
    Zhu, S
    Yue, G
    Shoemaker, RL
    Matalon, S
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 218 (01) : 302 - 308
  • [30] Do Ca2+-activated Cl- channels of pancreatic acinar cells show intrinsic inactivation?
    Kidd, JF
    Thorn, P
    JOURNAL OF PHYSIOLOGY-LONDON, 2000, 527 : 116P - 117P
12345